ABSTRACT
A common obstacle in clinical management of pathological pain is the poor response
to opioid analgesics. We now report that delta9-tetrahydrocannabinol (delta9-THC)-induced
antinociception remained effective in rats with pathological pain. The selective
central cannabinoid receptor antagonist SR141716A, but not the generic opioid
receptor antagonist naloxone, blocked the delta9-THC antinociception. Moreover,
there is no cross-tolerance between the antinociceptive effects of morphine
and delta9-THC in pathological pain states. The results indicate that delta9-THC
antinociception is both effective and independent of opioid receptors in rats
with pathological pain. Thus, the cannabinoid analgesic system may be superior
to opioids in alleviating intractable pathological pain syndromes.
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