Arthritis support forum
Eighty-eight subjects were randomized to receive 500 mg of glucosamine sulfate and one ibuprofen placebo capsule tree times daily, and the other 90 subjects received 400 mg of ibuprofen and glucosamine placebo capsules three times daily. arthritis support forum Wood joints. The duration of therapy was 4 weeks, followed by a 2-week drug-free interval. Pain scores were assessed for tenderness and for pain at rest and during movement using a 0 to 3 scale. Knee swelling was also assessed using a 0 to 3 scale. arthritis support forum Jaw pain cause. Physician evaluation of improvement was rated as worsened, unchanged, improved, or definitely improved (almost completely free of symptoms). No diagnostic criteria for osteoarthritis were given. Both groups showed statistically significant improvement in composite pain scores at 2 and 4 weeks of therapy. arthritis support forum Endometriosis-pain-treatment. Decrease in pain scores progressed throughout the study period and were sustained after a 2-week washout period at week 4. Glucosamine decreased pain scores by 57% and ibuprofen lowered these scores by 51%. Overall, the physician rating at 4 weeks identified 45% of subjects as symptom-free and 39% as improved in the glucosamine group, compared to 32% of subjects symptom-free and 45% as improved in the ibuprofen group. At the end of the 2-week wash-out period, however, the glucosamine group had a significantly better improvement rating than did the ibuprofen group, with 55% of the glucosamine-treated subjects being symptom-free compared with 36% in the ibuprofen group. Reginster et alref 6 conducted a randomized, double-blind placebo controlled trial examining the effects of glucosamine on the long-term progression of osteoarthritis. Two-hundred twelve patients with knee osteoarthritis were randomized to receive either 1500 mg glucosamine sulfate or placebo once-a-day for three years. Radiographs of each knee were taken at enrollment and after one and three years. The patients on placebo had a mean joint-space loss of -. 31 mm. Patients who had received glucosamine sulfate had a mean joint-space loss of -. 06 mm, a statistically significant finding. This indicates glucosamine sulfate may be able to slow the natural progression of osteoarthritis of the knee. Of note, there were no differences in safety or early withdrawal between the placebo and treatment groups. All of the published reports on clinical trials of glucosamine in OA have resulted in favorable outcomes. Unfortunately, many of these studies have significant flaws in experimental design. Nevertheless, the data from a few quality studies discussed above are suggestive that glucosamine is effective in the control of pain symptoms and is potentially a disease-modifying agent in the treatment of knee OA.
Arthritis support forum
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