Phantom limb pain
This potential mechanism is attractive as treatment for osteoarthritis because in OA proteoglycan production does not keep pace with its loss, resulting in a net loss of cartilage matrix. phantom limb pain Type of arthritis. High doses of oral glucosamine administered to rats had a mild anti-inflammatory effect in adjuvant-induced arthritis. Reicheltref 4) reported a large multicentric, randomized, double blind, placebo-controlled trial of glucosamine sulfate in osteoarthritis of the knee in 1994. Diagnosis was made based on the clinical and radiological criteria of Lequesne. phantom limb pain Treatment-osteo-arthritis. All patients were symptomatic with pain at rest or on movement and had functional limitations. One hundred fifty-five patients were randomized to receive either 400 mg of glucosamine sulfate or placebo intramuscularly twice weekly for 6 weeks. Assessment occurred on days 3 and 7 each week during the study period and at 2 weeks following the conclusion of the study. phantom limb pain Arthritis of the eye. A positive response to drug therapy was defined as a decrease in the Lequesne index of 3 points and the investigator's judgment of good or moderate effects. All patients in the study were symptomatic for at least 6 months prior to the study. Nonsteroidal anti-inflammatory drugs, corticosteroids, or other arthritis therapies were not allowed to be used by the subjects, except for acetaminophen as a rescue medication. Subjects needing acetaminophen for pain control were automatically classified as non-responders. Seventy-nine subjects were placed in the glucosamine group and 76 in the placebo group. There were 6 and 7 dropouts, respectively, but they were included in the intent to treat analysis. Two subjects receiving glucosamine and six receiving placebo-required acetaminophen and were considered to be nonresponers. Fifty-five percent of the glucosamine group was responders compared with 33 % of the group-receiving placebo, which is a statistically significant difference. Intent to treat analysis resulted in similar findings. The subjects receiving active therapy had significantly better improvement in the Lequesne index at 5 and 6 weeks than the placebo group, and the improvement was sustained at the 2- week post-treatment assessment. In both groups, there was a progressive improvement in symptom scores during the 6-week trial. This particular study was well designed.
Phantom limb pain
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