The Post War Years - "Adenovirus? What is that?"
In this chapter
you are a Military Virologist working out of Ft. Detrick Maryland.
The Hub of National
Viral Research.
Ten years, and
almost a half generation later (1954), military virologists notice a new
strain of a certain
respiratory virus
among troops entering basic training. The virus is found only in some new
borns, as a
specific type
of pneumonia, and in military recruits. Reasoning that a viral respiratory
"outbreak" would be
disastrous within
a closed population you are instructed to research this, "bug", along with
many of your
colleagues. The
virus appears to form from many troops being suddenly brought together
from around the
nation. You and
your fellow scientists can only imagine how this virus is formed! Sort
of a "National Virus" you reckon. Anyway, the virus exists in humans, only
in the lymph tissues of the throat (the tonsils and adenoids).
Of course you
must do research with this new virus in order to find an inoculation to
protect against it. The
virus is eventually
classified "Adenovirus" (pronounced: Ad-da-no virus), because of its origins
from adenoid
lymphatic tissue.
Lymphatic tissue plays a major role in mammalian immune systems, to include
humans.
Apparently, the
adenoid tissue acts as a screen, filtering out germs before they reach
the lungs. Remember,
the Adenovirus
is a "Respiratory Virus". We know it today as the "common cold". The lymph
tissue traps the
virus within
its cells. The body can then isolate the virus and attack it with major
immune system responses.
You extract the virus from the tissue and for the next 8 years exhaustive research is performed using this virus on lower life forms. The virus genome is described as a linear, double stranded; DNA. Genome monopartite. Total genome 30,000 - 42,000 nucleotides long. In 1998 scienntist use adenovirus vectors of 7,000-8,000 nucleotides long to "safely deliver gene therapy protocols".
In 1962 a scientist
drops some adenovirus on a mouse cell, in a petri dish, and studies his
observations. He
witnesses a cell
that quickly becomes tumorous. The birth of cancer research has occurred!
The following
years you and
your fellow scientist study this virus, extensively. It is found that the
virus can be used to easily manipulate genes during gene protocols. In
the late 1960's early 1970's it is decided to test, and eventually inoculate
all US Serviceman with this. This is a policy that will be in effect until
at least 1998. Every troop is given "not less than 32,000 live tissue culture
doses in each tablet". The military decides to protect its forces by inoculating
against both types 4, and 7. Each person is given 2 tablets to swallow
without chewing. Now, since this is a respiratory virus that has been converted
into an "entero" (intestinal) virus, the long term implications are not
known yet. In later years it will be found to have an affinity for hepatocytes,
or liver cells. It actually tries to help your body out by killing "virus
infected hepatocytes". The only problem is that if most of your liver cells
are infected by a "slow insidiously progressive virus", then eventually
most infected liver cells will be destroyed over time. The government,
because of the space program, begins to pump money into scientific research.
The public supports this move, initially, after Apollo 11 lands on the
moon in 1969.
Meanwhile, entire
Industries and Corporations are formed, and grow to become very influential.
In fact, they
have a major
resource problem . They can only get this Adenovirus from tonsils and adenoids.
People are not
going to let
you just "cut them out of their throats", and keep them ALL for research,
are they? Many tonsils
would be needed
for the amount of research allocated to be done on this. Everybody wants
a piece of the
action. There
are big dollars to be made from cancer research, and an eventual cure.
Not to mention, the
notoriety involved
for any institution, or person, derived from such a success. Maybe, a Nobel
prize in
genetics? You
retire from the Government and begin to work with one of these Major Research
Institutions.
Many of your
colleagues still work within the government and you are constantly coordinating
your work with
theirs. They
have an almost unlimited budget, but you do not. You spend years at this
institution of "higher
learning" studying
the virus and its effects on host organisms. You make contacts with the
newly formed
groups and are
made a "lucrative financial offer" from a large private corporation to
join their Board of
Directors. You
will have much say about this new industry's future course, and direction.
You will be permitted to continue your research work. For years to come
if you choose.
Your Industry
figures out how to have the government make policy decisions in your favor.
This is done the
old fashion way,
the American way, you buy access. You have moved up the career ladder of
your corporation, chiefly, because of your knowledge and influential contacts.
You form allied professional groups and eventually organize your "tonsil
collectors" and call them Doctor Associations and the Research Cancer
Society, or groups
like that. Every aspect of cancer research begins in earnest at this time
(during the early
1970's). Publicly
they announce that we are going to cure the Common Cold" ! Also, it is
declared that we will
defeat "Cancer
in our life time". The same sense of urgency prevailed as did during the
Second World War.
Jump, then think!
Big business, meaning big profits, meant that any errors would not be easily
admitted to -
now, or in the
years to come.
In order to test
this new cancer research virus, Adenovirus, it was decided by your industry
that the most
disadvantaged
persons of our society be tested. It was agreed to that the control group
would be prisoners,
that had life
sentences and could be thoroughly monitored in a controlled environment.
Of course, it would
have to be the
federal prison system. Possibly, even the military's own Leavenworth Prison.
The other group? Well, since it is Vietnam, we will test the lowest enlisted
coming in off the streets, uneducated. This will be our random group. We
will give the tablets to all troops of all services beginning in the late
1960's, early 1970's, and will continue to do so even to this day. Corporate
research will be subsidized in the name of National Security.
Influential scientists will make careers and build institutions of research in the name of advancement. You have become one of those famous Scientists!
Major advances are made in cancer research in the following years. The unsuspecting public lines up to donate their tonsils for research, unknowingly. Your institution gets much of the credit. This attracts the best and brightest minds in cancer research to your facilities. Millions are allocated in public funding to your institution, to continue your valuable work. You are paid handsomely, and the cycle begins! More Credentials, more money, more research! Because this is an emerging "New Scientific Field", no one but you and your industry understands the ramifications possible. You are whole-heartedly trusted by the government to monitor and provide for the public safety. This, you assure to all, you will do to the best of your abilities!
There is no genetic
research in the world today that does not involve Adenoviruses. They are
used to
manipulate genes
and are to be used with extreme caution! During your career, as virologist,
this was not fully understood or known. You retire a millionaire and are
held up as a role model to fellow researchers world wide.
It is 1975.
Your professional
writings are widely read, and other major avenues of research begins because
of
your hard dedicated
work, and commitment to scientific discovery. You have largely contributed
to a major
body of knowledge
that, it is believed at the time, will cure all existing disease and famine
from the planet. You receive all accolades and awards befitting your contributions.
The American Century has almost been realized!
To learn more
about Adenoviruses check out the only supplier of it in the world. These
are the people that
bring to us "Dolly
the sheep". Quantum Biotechnologies is located conveniently across our
boarders in
Canada. They
claim to supply all the genetic research equipment and materials for any
and all genetic research in the world! To learn about them and the Adenovirus
read their "Quantum Notes", located on their web page.
Behind the scenes, and coursing through the nation's blood, is our Yellow Fever and HBV serum virus mixture. In the 1970's some notice a marked increase in rates of liver cancer for certain groups of people. One of these groups are World War II Veterans. The liver is not fully understood in the 1970's, and besides, there is too much work to be done on other cancers and Heart Research. In society drug use becomes very prevalent in some areas, and the use of disposable syringes allows the public to experiment with Intravenous Drug use. The demographic breakdown of a typical active duty soldier, at this time, is a male, between the ages of 18 and 22. The leadership and moral in the US Armed Forces was at an all time low. Never had American Forces been so demoralized throughout America's past history. Many considered "Viet Nam" a war we lost. Others declared "Peace with Honor".
Since most cases
of liver problems showing up at medical facilities were either socio-economic
dregs,
(society's bottom
of the barrel) winos or they were admitted junkies, no one in a position
of influence placed
much emphasis
on curing these people. Today we would call them carriers of the virus.
Sort of a modern
"Typhoid Mary"!
The virus spends
years in the veins of soldiers and in the newly formed blood centers and
blood banks. Blood banking is growing, along side Heart Research, very
rapidly and they offer to pay money for donated blood. The lower income,
or poor, tend to need money more than the rich. They sell their blood to
support their lifestyles and even, maybe, their addictive habits. The virus
is also passed among hospital workers and in blood to blood contaminations,
among society's middle class. However, it remains undetected except by
prominent researchers
and scientists. They coin the phrase "Non-A Non-B Hepatitis". It is 1975.
The CDC has
been tracking
the disease for a year prior to that. They referred to it as "unspecified",
back then, and in 1982
officially began
to follow NANB with 2,629 reported cases for that year.
The Serum Hepatitis
Virus Mixture winds a crooked path and begins to slowly change itself,
genetically. This
will eventually
put it on a collision course with evolution, and the newly discovered miracle
virus - Adenovirus!