Dr. Mcgehee- The following is an appeals list for the second medical cell bio exam: Question #6 The answer given states that spontaneous activity in visceral smooth muscle may occur when a cell or group of cells exhibit an unstable resting membrane potential. While this is a correct answer, I also believe that there is another correct answer among the other choices. Answer E states that spontaneous activity in visceral smooth muscle is always irregular in frequency. According to the slide labeled Spontaneous Activity: Spike Potential in Dr. Cornett's lecture on Smooth Muscle physiology, a spontaneous spike discharge is asynchronous, which by definition means that it is neither concurrent nor regular. It does not say anywhere that spike discharges are never asynchronous, thus it is reasonable that one might think that spontaneous activity could always be irregular in frequency. Because of the confusion involved in the slide's information, I think answer E should also be a viable answer for question #6. Question #28 The answer to this question indicates that choices a, b, and c are all correct; however, this is incorrect. According to Dr. Winter's slide of the malate-aspartate shuttle titled A Better Representation (which he used solely to explain the entire process), there is a malate-alpha ketoglutarate antiport and a glutamate-aspartate antiport. There is no indication of an aspartate-malate antiport. According to the Cell text on page 491 (including the diagram), an antiport is a carrier protein that transports one molecule one way while transporting a different molecule the opposite way. It is apparent that there is no such malate-aspartate antiport involved in the shuttle, according to our lecture. Since answers a and b are still correct yet there is no answer that includes only a and b, I request that question #28 be thrown out due to there not being a single choosable correct answer. Question #61 According to how the question is asked, there are two possible answers for this question. The answer c is acceptable, but answer d is equally acceptable, if not more so. As indicated on page 426 of the Cell text, contractile bundles are made up of actin filaments organized by long, loose proteins called alpha actinins into crosslinked arrays. Thus they share similar qualities with filamin, and question #61 can have two possible answers. Therefore I request that both choices c and d be considered acceptable answers. Question #64 The information in this question comes from Chapter 13, which was not included as required reading for any of Dr. Kelly's lectures, nor were any of the lecture slides taken from this chapter.Dr. Kelly's lecture slides came predominantly from Chapter 11 and a few came from Chapter 12. Therefore, due to this information not being covered in our lectures, assigned chapters, or notes, I request that this question be thrown out. Question #86 Choice d should be an acceptable answer because decreased pancreatic insulin secretion would contribute more to Type I Diabetes, not Type II. Besides, why would increased glucose uptake from the digestive tract (choice c) not contribute to Type II? It would most certainly raise the blood glucose level and force extra work upon insulin production and reception, helping to bring about Type II. In any case, I request that choice d also be accepted as a correct answer to the question. Now wasn't that fun to read?! -Matt Lindberg, M1