Side effects of steroids
On the other hand, genomic actions are extremely rapid (<1 minute). side effects of steroids Effects of steroids. They are rapid because their effects involve an immediate modulation of the membranes of cells (particularly neural cells). These modulations may include changes to the permeability of the membrane, as well as effects on the opening of vital ligand gated ion channels. The end result is a quick and significant influence upon the activities of key areas of the brain, and the relevance of this to the medicinal use of androgenic hormones or prohormones should not be overlooked. side effects of steroids Videos-on-steroids. PARACRINE METABOLISMSo far I have briefly covered the basic mechanics of androgen activity in the central nervous system. However, one very important aspect of this has yet to be covered, and this concerns the "activation" of androgens at the CNS targets by enzymatic metabolism. Specifically speaking, the conversion of testosterone to its two most powerful metabolites; dihydrotestosterone (DHT) and estradiol. side effects of steroids Bodybuilding supplement reviews. One thing most people do not realize is that although testosterone is an active hormone, its primary function in some of the most vital areas of the body and the brain is as a prohormone. There are locations all over the CNS that are rich in 5 alpha-reductase, or aromatase, or both; in particular areas of the CNS that involve libido. It is in these areas that testosterone must first be converted to fully carry on its message. 5 alpha-reductase is found in high concentrations in various parts of the brain, particularly in the white matter. It is localized specifically in the myelin (outer fatty sheath of neurons). 5 alpha reductase (5-AR) converts testosterone into DHT, which is a much more potent androgen than testosterone. As a result, the androgenic signal of testosterone is "amplified" in 5-AR rich tissues. The significance of 5 alpha-reduction to the psychosexual actions of testosterone is made depressingly evident to many individuals that take finasteride (Proscar, Propecia) for prostate hypertrophy or male pattern baldness. In a considerable portion of these individuals a loss of libido and sexual function is experienced as a side effect, this despite a slight increase in circulating testosterone. Aromatase is the enzyme that catalyzes the conversion of androgens (androstenedione, testosterone) to estrogens. It also is found in certain areas of the brain in high concentration (often in conjunction with 5-alpha reductase), specifically in areas that are essential for the neuroendocrine control of gonadotropin secretion and sexual behavior. Androgens are well known to be essential to sexuality, but without the concomitant presence of estrogens they are essentially without effect. Studies have demonstrated that the abolition of estrogen formation through the use of aromatase inhibitors, or resulting from a congenital aromatase defect, greatly reduces sexual desire and function despite the presence of normal or high androgen levels. EAST GERMAN RESEARCHA group of East German scientists performed what is probably the most elaborate "practical" research on the psychological benefits of androgens. Their research did not center much on the prosexual effects of androgens, but rather on what they termed the "psychophysical" properties. The psychophysiological capacity, as the researchers describe it, is the ability of an individual to handle stress (physical, mental, and emotional).
Side effects of steroids
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