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Title |
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Histological Changes In The Uterus And Ovary Of The Albino Rat Following Oral Administration Of A-Chlorohydrin |
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BY |
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Fouad A.F.Ali*, Ali A.Abdel Rahman* and Ashraf M.Moustafa** *Plant protection Dept, faculty of Agriculture, Al-Azhar Univ; …..
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** Histology Dept., Faculty of Medicine, Al-Azher Univ.
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ABSTRACT |
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The antifertility effects of a- chlorohydrin were re-investigated in female albino rats. FemaIes were treated with a single oral dose (50 mq a.i/Kg. bw) of and six females were sacrificed at intervals of 1,3,7,14 and 21, days from treatment. The uterine changes were in the form of an increase lumenal folding with areas of metaplasia, some cellular vaculization and increased the collogen deposition in the endometrium. These changes were more noticed in 1s1,3rd, and 7th day of the drug intake. The ovarian changes were in the form of decreased number of growing follicles and absence of both Graafian follicles and corpora lutea. It is clear that, treatment of female rats with a chlorohydrin caused reversible uterine and ovarian changes. Uterine changes took longer time to recover compared with that of ovarian changes. These results support the possibility that this drug could be a functional female sterilant as it was known as a male sterilant. |