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Title |
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Prevalence of Renal Tuberculosis in Patients With Chronic Renal Failure Prior to Dialysis, Associated with Constitutional Symptoms |
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BY |
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Mona Hosny
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General Medicine Department Ain-Shams University |
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ABSTRACT |
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20 patients with chronic renal failure, not yet on dialysis, were included in the study. They were all females. They were divided into 2 groups according to etiology of renal failure: - Group (1): 10 patients with chronic renal failure due to diabetic nephropathy as D.M. is a predispasing factor for TB. Mean age of this group was (54.5 + 9.1) years. - Group (2) : 10 patients with chronic renal failure due to membrano – proliferative glomerulonephritis as it is the most common cause in Egypt for renal failure. Their mean age was (50.9 + 8.4) years. These 2 groups were compared with a third group of 10 normal controls. Constitutional and urogenital symptoms were a guide to choose patients included in the study. For all patients the following was done: Complete urine analysis, Acid-Fast Bacilli (AFB) in urine; Tuberculin test, chest X-Ray, Plain urinary tract, CT of (Kidneys – ureter – bladder) and PCR of Mycobacterium Tuberculosis in urine using Gen-Probe Amplification test. We found 4 patients out of 10 (40%) were positive for renal TB in Group (1), 3 patients out of 10 (30%) were positive for renal TB in Group (2), using PCR and other tests mentioned above. Prevalence rate of renal tuberculosis in group (1) is 40% and 30% in group (2) with a total of 35% in both groups, which cannot be ignored as a high prevalence rate in this study. We conclude that Diabetes Mellitus is a risk factor for renal Tuberculosis, but also chronic renal insufficiency in itself is another risk factor but to a lesser extent than DM. There was no significant statistical difference between chronic renal insufficiency due to diabetic nephropathy and chronic renal insufficiency due to membrano proliferative glomerulonephritis as regards renal Tuberculosis which was detected essentially by PCR of TB in urine. Compared to normal group, there were significant statistical differences in all parameters that were measured, between normal group and the other two groups together and separately.
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