Stem cells can
be programmed to become many kinds of tissue
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Scientists believe adult stem cells may be more flexible than
first thought.
Embryonic stem cells can
become any tissue, but adult ones are limited to the part of the
body they are in.
US researchers said evidence
had shown adult cells could be effectively fused with other
cells to work elsewhere, New Scientist magazine reported.
The Oregon Health and Science
University team said it meant adult stem cells may be useful in
fighting disease, but UK experts were less sure.
Critics of embryonic stem cell
research have argued it is not ethical to create human embryos
for stem cells only to destroy them.
As a result scientists -
particularly in the US where state funds cannot be used to fund
embryonic stem cell research - have been exploring ways of
treating disease with stem cells via adult cells.
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There are few stem cells that can fuse like
this

Stephen
Minger, of King's College London
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Previous research has shown
that adult cells can be fused with cells from other parts of the
body.
But because the fused cells
contain twice the number of chromosomes they have trouble
dividing, and struggle to replenish damaged tissue.
Markus Grompe, who led the
Oregon team, told the American Society for Cell Biology this
week that he had evidence that fused cells could reduce the
number of chromosomes to the normal number.
He said the process was called
"reduction divisions" and occurred routinely.
The theory is that cells are
pre-programmed to know how many chromosomes they have, and can
reduce their number if they have too many.
The researchers have shown
that mice with a disease called tyrosinemia type 1, which causes
jaundice and cirrhosis of the liver, can be cured by infusing
their livers with bone marrow stem cells.
Analysis suggested the cells
had reverted to the right number of chromosomes - the first time
this had been seen outside of insects.
However, why this happened was
not clear.
Dr Grompe is now investigating
whether it is possible to use a signalling molecule called
insulin-like growth factor 1 to speed up the process, as it is
too slow to be effective on many human conditions.
Disease
Arnold Kriegstein, who heads
the Institute for Stem Cell and Tissue Biology at the University
of California, said: "In much of the stem cell field, the
promise is way down the line.
"But this is something that
has already shown potential."
But Stephen Minger, director
of the Stem Cell Biology Laboratory at King's College London,
said fusion had limited potential.
"There are few stem cells that
can fuse like this, bone marrow stem cells are one.
"But I am not sure how useful
it is to spend time on this, when other sources such as
embryonic stem cells have the potential for much more.
"It has to be remembered this
is coming out of the US, there is a political agenda."
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