3-Aryl-5-furylpyrazolines and their biological activities

A. Cetin 1 *, A. Cansiz 1, M. Digrak 2

1Department of Chemistry, Faculty of Sciences and Art, University of Firat, 23169 Elazig, Turkey
2Department of Biology, Faculty of Sciences and Art, University of Sutcu Imam, K. Maras, Turkey

email: A. Cetin (acetin@firat.edu.tr acetin74@hotmail.com)

*Correspondence to A. Cetin, Department of Chemistry, Faculty of Sciences and Art, University of Firat, 23169 Elazig, Turkey

Funded by:
 FUNAF, Elazig, Turkey; Grant Number: 326

Abstract

 

Aryl-furyl substituted pyrazolines 2a-c and 4a-c were prepared by the reaction of ,-unsaturated carbonyl compounds with hydrazine or phenyl hydrazine. N-chloroacetyl derivatives 3a-c were obtained by the N-acetylation of 2a-c. The antibacterial activities of synthesized pyrazolines were examined by employing the disk-diffusion technique. All synthesized compounds showed antibacterial effects in 1200 g concentration.

 

© 2003 Wiley Periodicals, Inc. Heteroatom Chem 14:345-347, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10159


Received: 16 December 2002; Revised: 6 February 2003

 

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