Joseph L. Goldstein was born on April 18, 1940, in
Sumter, South Carolina, the only son of Isadore E. and Fannie Alpert Goldstein.
The family owned and operated
a clothing store in Kingstree, South Carolina,
a town of 5000 people. After his education in the primary and secondary public
schools of Kingstree, Goldstein attended Washington and Lee University in Lexington,
Virginia, and received the B.S. degree in chemistry, summa cum laude,
in 1962. He then attended Southwestern Medical School of the University of Texas
Health Science Center in Dallas where he was inspired to pursue a career in
academic medicine by Donald W. Seldin, then and now Chairman of the Department
of Internal Medicine. During his last year in medical school, Seldin offered
Goldstein a future faculty position if he would become trained in genetics and
return to Dallas to establish a division of medical genetics in the Department
of Internal Medicine. After receiving the M.D. degree in 1966, Goldstein moved
to Boston where he was an Intern and Resident in Medicine at the Massachusetts
General Hospital (1966-68).It was at the Massachusetts General Hospital that
Goldstein first met and developed a friendship with Michael S. Brown, his long-term
scientific collaborator.
After completion of his medical training, Goldstein spent two years (1968-70)
at the National Institutes of Health, where he worked in the laboratory of Marshall
W. Nirenberg and also served as a clinical associate at the National Heart Institute.
The opportunity to work in a first-rate basic science laboratory while at the
same time carrying a limited clinical responsibility proved highly influential
in shaping Goldstein's career. In
Nirenberg's laboratory, Goldstein and his
colleague C. Thomas Caskey isolated, purified, and worked out the mechanism
of action of several proteins required for termination of protein synthesis.
Here he acquired scientific skills and taste, experienced the thrill of discovery
and the excitement of science, and appreciated the power of a molecular biology
approach to human disease. As a clinical associate, Goldstein served as physician
to the patients of Donald S. Fredrickson, then Clinical Director of the National
Heart Institute and an expert on disorders of lipid metabolism. His curiosity
about hypercholesterolemia was aroused when he cared for patients with the striking
clinical syndrome of homozygous familial hypercholesterolemia. These patients
were intensively discussed with Brown. In view of his and Brown's common interest
in metabolic disease, Goldstein convinced his colleague to join him as a faculty
member at rape asian Goldstein video - sales white on Joseph L. bondage black the University - rape Goldstein L. Joseph animal videos of Texas Health Science Center at Dallas, where they
would work collaboratively on the genetic regulation of cholesterol metabolism.
While at the National Institutes of Health,
Goldstein and Brown became avid
duplicate bridge players. Their successful bridge partnership proved to be a
valid testing ground for their future scientific partnership.
Before returning to Dallas, Goldstein spent two years (1970-72) as a Special
NIH Fellow in Medical Genetics with Arno G. Motulsky at - Goldstein Joseph L. Трансформатор ТСЗ the University of Washington
in Seattle. Motulsky was one of the creators of human genetics as a medical
specialty. In Seattle, Goldstein initiated and completed a population genetic
study to determine the frequency of the various hereditary lipid disorders in
an unselected population of heart attack survivors. He and his colleagues discovered
that 20% of all heart attack survivors have one of three single-gene determined
types of hereditary hyperlipidemia.
One of these disorders was the heterozygous
form of familial hypercholesterolemia, which was found to affect 1 out of every
500 persons in the general population and 1 out of every 25 heart attack victims.
During his fellowship in Seattle, he became conversant with tissue culture techniques,
which proved to be invaluable in the subsequent studies with Brown.
In 1972, Goldstein returned to the University of Texas Health Science Center
at Dallas, where he was appointed Assistant Professor in Seldin's Department
of Internal Medicine and head of the medical school's first Division of Medical
Genetics. He became Associate Professor of Internal Medicine in 1974 and Professor
in 1976. In 1977, he was made Chairman саб разное проставки стойки L. Joseph т салону опоры и д - по короба под Goldstein of the Department of Molecular Genetics
L. movies Goldstein beast Joseph - free at the University complete Goldstein gallery - lingerie L. Joseph of Texas Health L. - Goldstein movies free Joseph beast Science Center at Dallas and Paul J. Thomas
Professor of Medicine and Genetics,
a position that he currently holds. In 1985,
he was named Regental Professor of the University of Texas.
Goldstein was elected to membership in the National Academy of Sciences in 1980.
He is also a member of the American Academy of Arts and Sciences, Association
of American Physicians, American Society for Clinical Investigation (President,
1985-86), American Society of Biological Chemists, American Society of Human
Genetics, American Society for Cell Biology, and the American Federation for
Clinical Research (National Council, 1979-82). He is also a Fellow of the American
College of Physicians and is a Diplomate of
the American Board of Internal Medicine.
Goldstein has served on study sections for the American Heart Association (1975-78)
and the National Institutes of Health (1975-78). He served on the Scientific
Review Board of the Howard Hughes Medical Research Institute (1978-84) and is
presently a member of its Medical Advisory Board (1985-present). In 1983 he
became a Non-resident Fellow of The Salk Institute for Biological Sciences.
He is, or has been, a member of the Editorial Board of the following journals:
Annual Review of Genetics (1979-84), Arteriosclerosis (1981-present),
Cell (1982-present), Journal of Biological Chemisty (1980-85),
Journal of Clinical Investigation (1977-82), and Science (1985-present).
He has received honorary Doctor of Science
degrees from the University of Chicago
(1982) and Rensselaer Polytechnic Institute (1982). His other academic honors
include membership in Phi Beta Kappa and Alpha Omega Alpha. He was also the
recipient of the Ho Din Award for Outstanding Medical School Graduate of the
University of Texas Southwestern Medical School (1966) and of a Research Career
Development Award from the National Institutes of Health (1972-77).
In addition to the 1985 Nobel Prize for Physiology or Medicine, Goldstein and
his colleague Brown have been jointly honored for their research with the following
awards: Heinrich Wieland Prize for Research in Lipid Metabolism (1974); Pfizer
Award for Enzyme Chemistry of the American Chemical Society (1976); Albion O.
Bernstein Award of the New York State Medical Society (1977); Passano Award
(1978); Lounsbery Award of the U.S. National Academy of Sciences (1979); Gairdner
Foundation International Award (1981);
New York Academy of Sciences Award in
Biological and Medical Sciences (1981); Lita Annenberg Hazen Award (1982); V.D.
Mattia Award of the Roche Institute of Molecular Biology (1984); Distinguished
Research Award of the Association of American Medical Colleges (1984); Research
Achievement Award of the American Heart Association (1984); Louisa Gross Horwitz
Award (1984); 3M Life Sciences Award of the Federation of American Societies
for Experimental Biology (1985); William Allan Award of the American Society
for Human Genetics (1985); and the Albert D. Lasker Award in Basic Medical Research
(1985).
Goldstein and his colleague Brown have shared the podium for a number of distinguished
lectureships, including the Harvey Lecture (1977), Christian A. Herter Lectures
at Johns Hopkins University (1979), Harry Steenboch Lectures at the University
of Wisconsin at Madison (1980); Smith, Kline, and French Lectures at the University
of California, Berkeley (1981); Duff Memorial Lecture of the American Heart
Association (1981); Doisy Lectures at
the University of Illinois at Urbana-Champaign
(1983); the first Pfizer Lecture in Honor of Konrad Bloch at Harvard University
(1985); and the Berzelius Lecture at the Karolinska Institute, Stockholm (1985).
From Les Prix Nobel. The Nobel Prizes 1985, Editor Wilhelm Odelberg, [Nobel Foundation], Stockholm, 1986
This autobiography/biography was written at the time of the award and later published in the book series Les Prix Nobel/Nobel Lectures. The information is sometimes updated with an addendum submitted by the Laureate. To cite this document, always state the source as shown above.