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Pneumonia in immunocompromised host

Definition

Pneumonia in an immunocompromised host describes a lung infection that occurs in a person whose ability to fight infection is greatly impaired.

Causes, incidence, and risk factors

People who are immunocompromised have a defective immune response. Because of this, they are susceptible to infections by germs (microorganisms) that are everywhere, but do not cause disease in healthy people. They are also more vulnerable to the usual causes of pneumonia, which can affect anyone.

Immunosuppression can be caused by HIV infection, leukemia, organ transplantation, bone marrow transplant, and medications to treat cancer.

Symptoms

  • Nonproductive (dry) cough or cough with mucus-like, greenish, or pus-like sputum
  • Chills with shaking
  • Fever
  • Easy fatigue
  • Chest pain that is:
    • Sharp or stabbing
    • Increased by deep breathing
    • Increased by coughing
  • Headache
  • Loss of appetite
  • Nausea and vomiting
  • General discomfort, uneasiness, or ill feeling (malaise)
  • Shortness of breath

    Additional symptoms that may occur:

    • Joint stiffness (rare)
    • Muscle stiffness (rare)
    • Swollen glands
    • Excessive sweating or night sweats

Signs and tests

Crackles or other abnormal breath sounds may be heard when listening to the chest with stethoscope (auscultation). Lack of breath sounds can be an important sign.

Tests include:

Treatment

The goal of treatment is to get rid of the infection with antibiotics or antifungal agents. The specific drug used will depend on what kind of organism is causing the problem. One drug may kill one type of organism, but not another.

Respiratory treatments (to remove fluid and mucus) and oxygen therapy are often needed.

Expectations (prognosis)

The outcome may be poor if the pneumonia is caused by a virus or fungus, or if the patient is severely immunosuppressed.

Complications

  • Respiratory failure
  • Death

Calling your health care provider

Call your health care provider if you are immunosuppressed and you have symptoms of pneumonia.

Prevention

Limit exposure of immunocompromised people to others who are ill.

Illustrations

Pneumococci organism
Pneumococci organism
Lungs
Lungs
The lungs
The lungs
Respiratory system
Respiratory system

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Pneumonia in immunodeficient patient