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Megaloblastic anemia

Definition

Megaloblastic anemia is a blood disorder characterized by anemia, with red blood cells that are larger than normal, usually resulting from a deficiency of folic acid or of vitamin B-12.

Causes, incidence, and risk factors

Deficiencies of vitamin B-12 and folic acid are the most common causes of megaloblastic anemia. Other causes are leukemia, myelofibrosis, multiple myeloma, certain hereditary disorders, drugs that affect DNA synthesis such as chemotherapy agents (methotrexate), alcohol, and other causes. Risk factors relate to the causes. (See also pernicious anemia).

Symptoms

Signs and tests

Examination of neurological signs may show abnormal reflexes, decreased position sense, and decreased vibration sense if related to vitamin B-12 deficiency.

Tests include:

Treatment

The objective of treatment is to determine the cause of the anemia, and the treatment depends upon the cause. Anemias related to vitamin deficiencies are discussed separately.

Expectations (prognosis)

The outcome is expected to be good with treatment.

Complications

Complications vary with the underlying cause.

Calling your health care provider

Call for an appointment with your health care provider if symptoms develop.

Prevention

Adequate intake of vitamin B-12 and folic acid is helpful.

Illustrations

Megaloblastic anemia - view of red blood cells
Megaloblastic anemia - view of red blood cells
Hypersegmented PMN (Close-up)
Hypersegmented PMN (Close-up)
Blood cells
Blood cells

Page Content:

Anemia - megaloblastic ; anemia megaloblastic