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CPKDefinition A CPK is a blood test that measures creatine phosphokinase (CPK), an enzyme found predominantly in the heart, brain, and skeletal muscle. When the total CPK level is substantially elevated, it usually indicates injury or stress to one or more of these areas. How the test is performed Blood is drawn from a vein, usually from the inside of the elbow or the back of the hand. The puncture site is cleaned with antiseptic. An elastic band is placed around the upper arm to apply pressure and cause the vein to swell with blood. A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. During the procedure, the band is removed to restore circulation. Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding. In infants or young children: The area is cleansed with antiseptic and punctured with a sharp needle or a lancet. The blood may be collected in a pipette (small glass tube), on a slide, onto a test strip, or into a small container. A bandage may be applied to the puncture site if there is any bleeding. This test may be repeated over 2 or 3 days for a hospitalized patient. The pattern of a rise or fall in CPK (or CPK isoenzymes) can be diagnostically significant. How to prepare for the test Usually, no special preparation is necessary. How the test will feel When the needle is inserted to draw blood, you may feel moderate pain, or only a prick or stinging sensation. Afterward, there may be some throbbing. Why the test is performed When a muscle is damaged, CPK leaks into the bloodstream. Determining which isoenzyme (specific form of CPK) is elevated will help determine which tissue has been damaged. This test may be used to:
What abnormal results mean Higher than normal total CPK levels may be seen withconditions such as the following:
What the risks are
Special considerations Other tests should be conducted to determine the exact location of muscle damage. Factors that may affect test results include cardiac catheterization, intramuscular injections, trauma to muscles, recent surgery, and vigorous and prolonged exercise. Drugs that can increase CPK measurements include amphotericin B, ampicillin, some anesthetics, anticoagulants, aspirin, clofibrate, dexamethasone, furosemide, morphine, alcohol, and cocaine. Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample may be more difficult from some people than from others. Illustrations
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