Blood transfusion steroids
If similar percentages of ARs are active - close to 100% in each case -- then why do higher doses give more results? It's a fact that they do, but there is not any large percentage of unoccupied receptors at the moderate dose. blood transfusion steroids Steroid user pictures. Thus, there is little room for improvement there. So at least part of the cause must be something other than simply occupying a higher percentage of receptors. And why did I pick those doses, rather than comparing normal levels with say 400 mg/ week?The fact that the ARs must form dimers to be active has an interesting consequence. blood transfusion steroids Steroids for sale. The mathematics are such that if two ARs must join together to form an activated dimer, and both must bind a molecule of AAS, then the square must be taken of the percentage. This means that if say 71% of receptors are binding steroid, only 50% of the dimers will be activated. Thus, at low levels, there is more room for improvement than one would think. blood transfusion steroids Female muscle gallery. But if say 95% are occupied, then even after squaring that, there would still only be 10% room for improvement. But actual improvement - increase in effect - seems to be much more than 10%. Anabolism increases even as the dose becomes more than sufficient to ensure virtually complete binding. Why?One popular explanation is that high doses of AAS block cortisol receptors and are thus anti-catabolic. But if this were an adequate explanation, then one could use anti-cortisol drugs together with low doses of AAS and get the same results as with high doses of AAS. This isn't the case. In fact, if cortisol is suppressed, this simply results in painful joint problems. And if the cortisol-blocking theory were true, we also would expect that persons with abnormally low cortisol ought to be quite muscular. That isn't the case either. Three other possibilities come to mind: Possible Explanations for the Effect of High Dose Anabolic- Androgenic SteroidsHigh doses of AAS could upregulate AR productionAlthough activity cannot be greatly increased by increasing occupancy of existing receptors, it might potentially be greatly increased by increasing the number of receptors. This is mentioned here as a possible explanation for the effects of high dose AAS, not as an established observed fact in muscle tissue of bodybuilders. I am not aware of any such studies. Upregulation is observed from supraphysiological doses of nonaromatizing AAS in other tissues, and is observed in humans in response to resistance exercise. High doses of AAS could stimulate growth independently of the ARIn muscle tissue, androgen has been observed to activate the immediate-early gene zif268 in a process not involving the AR. This activity is almost certainly related to muscle growth, and it requires high doses. Testosterone is observed to increase the efficiency of mRNA translation of cellular proteins, and this may be mediated by a mechanism independent of the AR. Nerve tissue has been observed to respond almost instantly to androgen.
Blood transfusion steroids
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