CHRONIC RENAL FAILURE                                                                                                                                                      KIDNEY    HOME
                                                                                                                                                              DISEASE

The term uremia, though it is sometimes used as if it were interchangeable with chronic renal failure, really means an increase in the concentration of urea in the blood. This can arise in many acute illnesses in which the kidney is not primarily affected and also in the condition of acute renal failure described above. Uremia ought to represent a purely chemical statement, but it is sometimes used to denote a clinical picture, that of severe renal insufficiency.
As with acute renal failure, there are many conditions that can lead to chronic renal failure. The two most common causes are pyelonephritis and glomerulonephritis (kidney inflammation involving the structures around the renal pelvis or the glomeruli), and other common causes are renal damage from the effects of high blood pressure and renal damage from obstructive conditions of the lower urinary tract. These primary disorders are described below. They have in common a progressive destruction of nephrons, which may be reduced to less than a 20th of their normal number. The quantitative loss of nephrons can account for the majority of the changes observed in chronic renal failure; the failure in excretion is due directly to loss of glomerular filters, and other features such as the large quantities of dilute urine represent a change in tubular function that could be accounted for by the increased load that each remaining nephron has to carry. There are many other causes of chronic renal failure aside from the four common ones. They include congenital anomalies and hereditary disorders; diseases of connective tissue; tuberculosis; the effects of diabetes and other metabolic disorders; and a number of primary disorders of the kidney tubules. Of the many causes, there are some that have importance out of proportion to their frequency, by virtue of their reversibility; these include renal amyloidosis (abnormal deposits in the kidney of a complex protein substance called amyloid), whose causes may be treatable; damage to the kidney from excessive calcium or deficiency of potassium; uric acid deposition in gout; the effects of analgesic agents (substances taken to alleviate pain) and other toxic substances, including drugs.
The person suffering from renal failure, especially in the early stages, may have no symptoms other than a feeling of thirst and a tendency (shared with many normal people) to pass urine at frequent intervals and through the night; or he may be in a coma, with occasional convulsions. The general appearance of the sufferer may be sallow because of a combination of anemia and the retention of urinary pigment. Even if not in actual coma, the affected person may be withdrawn; muscle twitchings and more general convulsions may occur. The coma is thought to represent poisoning, and convulsions are often related to the severity of the high blood pressure that commonly complicates advanced renal failure. Blurred vision is also a manifestation associated with high blood pressure. Bruising and hemorrhages may be noticeable.
Although the toxin (or toxins) of uremia has yet to be identified, the rapid improvement that follows dialysis points strongly to a toxic component. Urea itself is not notably toxic. Not all the chemical alterations in uremia are simple retentions. There is acidosis--a fall in the alkalinity of the blood and tissue fluids--reflected clinically in deep respiration as the lungs strive to eliminate carbon dioxide. The capacity of the kidney to adjust to variation in intake of salt, potassium, and water becomes progressively impaired, so that electrolyte disturbances are common. Poor appetite, nausea, vomiting, and diarrhea are common in uremic patients, and these in turn add another component to the chemical disturbance. Phosphate is retained in the blood and is thus associated with low blood levels of calcium; the parathyroids are overactive in renal failure, and vitamin D is less than normally effective because the kidneys manufacture less of its active form (1,25-dihydroxycholecalciferol). (Parathyroid hormone causes release of calcium from the bones, and vitamin D promotes absorption of calcium from the intestines.) These changes can lead to severe bone disease in persons suffering from renal failure, because bone calcium is depleted and the calcium stores are not adequately replenished.
In chronic renal failure, excessive production of renin by the kidney can lead to severe high blood pressure (hypertension), and the effects of this may even dominate the clinical picture. In addition to damage to the brain and the retina, the high blood pressure may lead directly to heart failure. Hypertension can also accelerate the progress of renal damage by its impact on the renal blood vessels themselves, setting up a cycle that can be hard to break. Anemia is also often severe due in part to a failure to produce erythropoietin.
The patient in advanced renal failure is vulnerable to infection and other complications, such as vomiting or diarrhea, which need special care. When symptoms of advanced renal failure appear, deterioration can be delayed by a strict low-protein diet, 18-20 grams of high-quality protein each day. In terminal renal failure, the affected person can be rescued only by some form of dialysis and then maintained by dialysis or transplantation.