Drugs in CVS.
b- blockers: Blockade of b1 adrenoreceptors is negatively inotropic and chronotropic, and delays AV conduction. Blocked of b2 receptors causes coronary and peripheral vasoconstriction and bronchoconstriction. b1 receptors are atenolol, metoprolol etc.
b- blockers are used to diminish myocardial oxygen demand in coronary artery disease, to control hypertension and certain arrhythmias, and beneficial effect prophylactically following an MI
CI: asthma, obstructive airway disease, claudication, and heart failure/heart block
SE: nightmares, depression, decreased glucose tolerance, lethargy, impotence, and headache etc.
Diuretics: used in hypertension and heart failure.SE: frusemide: hypokalaemia, ototoxicity. Thiazides: hypokalaemia, hypomagnesaemia, glucose and ¯ platelets
Vasodilators: ¯ BP in hypertension, decrease the work of the heart in heart failure and coronary artery disease.
Venodilators: nitrates, arterial dilators: hydralazine
ACE inhibitors also act by vasodilation.
SE: hypotension and dizziness.
Aspirin: prevents blood clotting
GI upset and black stool.