 |
Fibrinolysis in cutaneous vasculitis |
|
Fibrinolysis in lividoid vasculitis. |
|
Leucocytoclastic vasculitis associated with hepatitis C and cryoglubulinaemia. |
|
Comparative study of daivonex and narrow band UVB versus daivonex and PUVA in the treatment of vitiligo |
|
Narrow band in vitiligo |
|
Narrow band in psoriasis |
Abnormal
fibrinolysis, determined by the relative concentrations of plasma tissue
plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1), has
been demonstrated in patients with cutaneous necrotizing vasculitis (CNV). ELISA
tests were performed to detect levels of plasma t-PA & PAI-1 in 40 patients
and 13 controls. Post-occlusive t-PA & PAI-1 levels were measured in 9
patients and 6 controls. Patients were subdivided into two groups; early: lesion
duration < 2 weeks and late: lesion duration ³
2 weeks. Results of the study show an early hyperfibrinolytic stage with high
t-PA and a late hypofibrinolytic stage with low t-PA . No significant changes
were detected in PAI-1 levels in both groups. Post-occlusive t-PA & PAI-1
levels were significantly elevated than pre-occlusive levels. It is concluded
that there exists a dynamic state in the fibrinolytic system in case of CNV; an
early hyperfibrinolytic stage and a late hypofibrinolytic stage.
cutaneous
necrotizing vasculitis; Fibrinolysis; fibrin degraded products (FDP); tissue
plasminogen activator (t-PA); plasminogen activator inhibitor 1 (PAI-1).