U.S. Federal Route 40 is the main east-west surface highway across Central Muskingum County. This runs along the Interstate 70 corridor. U.S. Rt. 40 passes through the following towns in Muskingum County. Gratiot Hopewell Mount Sterling Zanesville Norwich New Concord U.S. Rt. 40 is multi-plexed in Muskingum County. U.S. Rt. 22, from Zanesville to the Muskingum/Guernsey County. Ohio State Route 93, near Zanesville. U.S. Rt. 40 intersects the following highways in Muskingum County. Interstate 70, near Zanesville. U.S. Rt. 22, at Zanesville. Ohio State Route 60, at Zanesville. Ohio State Route 93, at Zanesville. Ohio State Route 146, at Zanesville. Ohio State Route 93, near Zanesville. Ohio State Route 797, near Norwich. Interstate 70, near Norwich. Ohio State Route 83, at New Concord.
