Self-recommend2

(Continued)

I continued the research line and other aspects of transplant immunology research under the support of Roche Organ Transplantation Research Foundation as a key co-researcher since last year. The fund is $65,000 per year for 3 years [Ref ]. The researches on the role of CD28 and CTLA4 co-stimulatory molecules and the role of NF-kB signaling in allograft rejection and the introduction of tolerance, mostly using murine abdominal and cervical heart transplantation and skin transplantation models, have produced at least 2 papers and 2 presentations.

As key co-researcher, I also involved in the research of transplant immunology in islets transplantation models, funded by State of Illinois in this year [Ref ]. The fund is $100,000 for one year. This research is in proceeding and has yield promising initial results. It is expected to be productive in fabulous findings.

This has been the most productive period in my life. I have published eleven primary papers, and given six oral presentations based on the research I undertook at the University of Chicago.

6. Important Title, Position and Memberships

My professional titles and positions are the following

ˇ Assistant Professor and Instructor in Transplant and General Surgery. Associate Director, Institute of Organ Transplantation, Tongji Hospital Tongji Medical University, 07/1991 - 1994

ˇ Associate Professor, Associate Chief Surgeon in General and Transplant Surgery. Associate Director, Institute of Organ Transplantation, Tongji Hospital, Tongji Medical University, 1994 - 09/1996

ˇ Research Associate, Section of Transplantation, and recently, Section of Rheumatology, The University of Chicago, 05/1997 - present.

ˇ Research Associate (Instructor), Section of Rheumatology, the University of Chicago, anticipated October 2001.

I also hold positions in various journals and associations:

ˇ Standing Member of the Editorial Board of the ŤChinese Journal of Organ Transplantationť, China's number one academic journal for the transplantion community, 1993 - 1998. I was responsible for viewing and editing all the Chinese and English abstracts for all the papers published in this journal, and for peer-viewing some of the full papers.

ˇ Member of Editorial Board, and the First English Editor of ŤJournal of Clinical Surgeryť, 1993-1999. I was responsible for peer-viewing and editing some of the full papers and English abstracts.

ˇ Contributing Editor, ŤJournal of Enteral and Parenteral Nutritionť, 1995-2000, and ŤActa Universitatis Medicinae Tongjiť, ŤMedicine and Societyť, 1994- 2000.

ˇ Contributing Editor, ŤJournal of Popular Medicineť, ŤNews Healthť, ŤWuhan News Healthť, ŤChangJiang Dailyť, 1994-2000.

I am a member of the following national and international associations

ˇ Member, International Society of Experimental Microsurgery, since 1998.

ˇ Member, Transplantation Society (International), since 1998.

ˇ Member, American Society of Transplantation, since 1999.

ˇ Member, American Association of Immunologists, since April 2000.

ˇ Member, Chinese Medical Association, since 1984.

ˇ Member, Chinese Society of Transplantation, since 1985.

7. Main Achievements

In this section, I will only include the main awards, papers, books and presentations. Please note a different rule between China and America in authorship for awards and publications. In China, the most important author is the first author. Promotion in title and position and salary raise are granted to the first author. The importance will be reduced gradually in turn to the 2nd author, the 3rd author, and so on. I contributed to many papers and awards in which I was not the first author but thought it was not important to list them in my resume when I was in China. As a result, I only recorded and listed awards and publications in which I am the first author. But in America, the rule is somewhat different and I have begun listing all the papers I have contributed to.

ˇ Young Investigator Award

In May 1999, I won this prestigious award conferred by ASTS (American Society of Transplant Surgeons) in the Combined Annual Scientific Meeting of AST (American Society of Transplantation) and ASTS. Every year, thousands of scientific papers from all over the world are submitted to this world top academic meeting for transplantation science. Only about one third of these papers are selected to be presented at this meeting. And only the top fifteen papers first-authored by young researchers can be elected to get this world-renowned award. The authors and the title of the research are as follows:

Ping Zhou, Gregory L. Szot, Arlene H. Sharpe, Gang He, Oliver Kim, Kenneth A. Newell, Jeffery A. Bluestone, and J. Richard Thistlethwaite. "Murine allogeneic heart graft rejection is dependent on indirect B7 mediated costimulation".

All other awards were conferred by academic Chinese societies or committees in China. I am the first author in all of the following awards recorded below.

ˇ 12/1998, "Research on orthotopic abdominal visceral cluster transplantation and its related surgical techniques", the 2nd Prize of Advanced Science and Technology Award, Hubei Province, China. This is a state level award.

ˇ 10/1995, "Orthotopic abdominal cluster transplantation for the treatment of upper abdominal malignancies", the 2nd Prize of National Outstanding Academic Paper by Middle-aged and Young Investigators granted by Chinese Association of Transplantation. This is a national level award.

ˇ 10/1993, "Improved techniques for fetal cadaver multiple organ harvesting", the 3rd Prize of 5th Annual Natural Scientific Outstanding Academic Paper Award of Hubei Province, China. This is a state level award.

ˇ 10/1993, "Pathological studies of abdominal organ cluster grafts", the 2nd Prize of 5th Annual Natural Scientific Outstanding Academic Paper Award of Hubei Province, China. This is a state level award.

ˇ 10/1993, "SPECT evaluation on CsA caused nephrotoxicity in kidney transplant recipients", the 1st Prize of Outstanding Academic Paper, Association of Medical Specialists of South-Middle China. This is a semi-national level awards.

ˇ 07/1992, "Research on allogeneic heterotopic abdominal multiple organ transplantation in dogs", the 1st Prize of 4th Annual Natural Scientific Outstanding Academic Paper Award of Hubei Province, China. This is a state level award.

ˇ 12/1989, "Experimental and clinical research on fetal kidney transplantation", Outstanding Thesis Award, Chinese Medical Association, Wuhan Branch, China. This is a city level award.

Book chapters (In Chinese publication):

I wrote chapters in three important professional textbooks or professional books. I am the first or the single author for all those chapters:

1. I wrote the chapter "The Source of Organ Donors" and "Social Issues and Influences of Organ Transplantation" in ŤMedical Sociologyť. The Principle Editor of the book is Professor Hao-Li Zhou. This is the first edition published in 1992. The book was then used as textbook of medical ethics for medical students in some universities in China.

2. I was in charge of in two chapters, "SPECT Evaluation in Organ Transplantation" and "Multiple Organ Transplantation (I am the 2nd author in this chapter)" in ŤTransplatologyť. It was the 1st edition and published in 1994. The Main Editor is the Chinese transplant pioneer, Professor Sui-Sheng Xia. This was the first and also the only transplantation professional book in China at the time. Compared with the book below published five years later, this book emphasizes basic scientific knowledge and the whole transplantation profile. It was the first academic scientific book available to the transplant community in China.

3. Single authored in three chapters, "Organ Donors and Donation", "Organ Preservation and Preservation Solutions" and "Combined Multiple Organ Transplantation" in the book entitled ŤClinical Transplantationť. It was the 1st edition and published in 1999. Main Editor Sui-Sheng Xia. Compared with book above published three years before, besides describing more modern developments in transplantation, this book mainly emphasized more practical aspects of transplantation. It is the first and also the only complete professional book for transplant practice until now in China.

All the main, peer-viewed, first authored papers published in China

1. Ping Zhou, Suisheng Xia, Duengui Liu, et al. Administration of CsA in fetal kidney transplant recipients. Chinese Journal of Organ Transplantation 1990; 11: 31.

2. Ping Zhou, Suisheng Xia, Shi Chen, et al. Heterotopic abdominal organ cluster transplantation in dogs. Chinese Journal of Organ Transplantation 1991; 12: 52.

3. Ping Zhou, Suisheng Xia. Abdominal multiple visceral transplantation (Review paper). Chinese Journal of Organ Transplantation 1991; 12:152.

4. Ping Zhou, Hui Guo, Suisheng Xia, et al. Pathological studies of abdominal organ cluster grafts. Chinese Journal of Experimental Surgery 1992; 9: 199.

5. Ping Zhou, Duengui Liu, Suisheng Xia, et al. Improved techniques for fetal multiple organ harvesting. Chinese Journal of Organ Transplantation 1993; 14: 186.

6. Ping Zhou, Duengui Liu. Parenteral nutrition in kidney transplant recipients. Chinese Journal of Clinical Nutrition 1993; 1(2): 199.

7. Ping Zhou. Social factors influencing organ donation and the resolving methods. Journal of Medical Sociology 1993; 6: 19.

8. Ping Zhou, Fanjun Zeng, Suisheng Xia, et al. Heavy bleeding of gastrointestinal tract in kidney transplant recipients. Journal of Clinical Surgery 1994; 2: 318.

9. Ping Zhou, Hua Wu, Suisheng Xia, et al. SPECT evaluation on ATN in kidney transplant recipients. Chinese Journal of Experimental Surgery 1994; 11(3): 133.

10. Ping Zhou, Suisheng Xia, Yintian Zhang, et al. Orthotopic en bloc abdominal multivisceral transplantation - one case report. Chinese Journal of Organ Transplantation 1994; 14: 750.

11. Ping Zhou, Suisheng Xia, Duengui Liu, et al. Experimental studies on operative models and surgical techniques for abdominal multivisceral transplantation. Chinese Journal of Organ Transplantation 1995; 16: 169.

12. Ping Zhou, Hua Wu, Fanjun Zeng, et al. SPECT diagnosis for upper urinary tract obstruction in renal transplant recipients. Chinese Journal of Organ Transplantation 1996; 17(2): 80.

13. Ping Zhou, Duengui Liu, Fanjun Zeng. Parenteral Nutrition in renal transplant recipients with severe complication. Chinese Journal of Enteral and Parenteral Nutrition. 1995; 3(2): 11.

14. Ping Zhou, Suisheng Xia, Dungui Liu, et al. Clinical abdominal multiple visceral transplantation for the treatment of upper abdominal malignancies. Journal of Clinical Surgery 1996; 4(3): 182.

15. Ping Zhou, Fanjun Zeng, Suisheng Xia, et al. Diagnosis and treatment of hemorrhagic abdominal surgical complications in renal transplant recipients. Chinese Journal of Organ Transplantation 1996; 17(3): 117-119.

16. Ping Zhou. Legislation of transplantation and the current status in China. Journal of Medicine and Society 1996; 9(2): 128.

17. Ping Zhou. Economical analysis and the current status in transplantation in China. Journal of Medicine and Society 1996; 9(4): 24.

18. Ping Zhou, Dungui Liu, Suisheng Xia, et al. Significance of quaternary therapy for severe acute pancreatitis. Journal of Clinical Surgery 1996; 4(4): 202-204.

19. Ping Zhou, Suisheng Xia, Dungui Liu, et al. Orthotopic abdominal multiple visceral transplantation. Acta Universitatis Medicinae Tongji 1996; 25(4): 305-308.

Peer-viewed papers published in America:

1. Ping Zhou, Gregory L. Szot, Jeffrey A. Bluestone, J. Richard Thistlethwaite et al. Murine allogeneic heart graft rejection is dependent on indirect B7 mediated costimulation. Transplantation 1999; 67(9): S590.

2. Ping Zhou, Gregory L. Szot, Jeffrey A. Bluestone, J. Richard Thistlethwaite et al. Absence of host B7 expression is sufficient for long-term murine vascularized heart allograft survival. Transplantation 2000; 69(5): 904. [Published erratum correction on authorship appears in Transplantation August 27, 2000, Vol.70(5), 707]

3. Kenneth A. Newell, Gang He, Zhong Guo, Oliver Kim, Gregory L. Szot, Ingrid Rulifson, Ping Zhou, John Hart, J. R. Thistlethwaite, and Jeffery A. Bluestone. Blockade of the CD28/B7 costimulatory pathway inhibits intestinal allograft rejection mediated by CD4+ and CD8+ T cells. Journal of Immunology 1999; 163(5): 2358-2362.

4. Ping Zhou, Greg L. Szot, Christine Guo, Oliver Kim, Gang He, Jun Wang, Michael J. Grusby, Kenneth A. Newell, J. Richard Thistlethwaite, Jeffrey A. Bluestone, Maria-Luisa Alegre. Role of STAT4 and STAT6 signaling in allograft rejection and CTLA-Ig-mediated tolerance. Journal of Immunology 2000; 165(10): 5580-5587.

5. Ping Zhou, Greg L. Szot, Zhong Guo, Gang He, Jun Wang, Kenneth A. Newell, J. Richard Thistlethwaite, Jeffrey A. Bluestone, Maria-Luisa Alegre. Signaling through STAT4 and STAT6 in not required for acute allograft rejection or for the induction of tolerance by CTLA4-Ig treatment in a murine cardiac model. Transplantation 2000; 69(8): S379.

6. Ping Zhou, Greg L. Szot, Zhong Guo, Oliver Kim, Gang He, Jun Wang, Michael J. Grusby, Kenneth A. Newell, J. Richard Thistlethwaite, Jeffrey A. Bluestone, Maria-Luisa Alegre. STAT6 signaling may be necessary for tolerance induction by CTLA-Ig. Transplantation Proceedings, 33:214-216, 2001.

7. Maria-Luisa Alegre, Francesca Fallarino, Ping Zhou, Ken Frauwirth, Kenneth A. Newell, Thomas Gajewski. Immune regulation through the CD28/CTLA4/B7 pathway. Transplantation Proceedings 33(1 - 2): 209-211, 2001.

8. Greg L. Szot, Ping Zhou, Jun Wang, Zhong Guo, Kenneth A. Newell, J. Richard Thistlethwaite, Jeffrey A. Bluestone, Maria-Luisa Alegre. Role of CD8+ T cells in cardiac allograft rejection in wild type and CD28-deficient mice. Transplantation 2000; 69(8): S413.

9. Ping Zhou, Gregory L. Szot, Ingrid Rulifson, Jun Wang, Zhong Guo, Oliver Kim, Kenneth A. Newell, J. Richard Thistlethwaite, Jeffrey A. Bluestone, and Maria-Luisa Alegre. Different Mechanisms of Cardiac Allograft Rejection in Wildtype and CD28-Deficient Mice. Accepted and soon will be published in American Journal of Transplantation 1(1): 38-46, 2001.

10. Ping Zhou, Kwang Woo Hwang, Jun Wang, Christine Guo, Mary Markiewicz, Oliver Kim, Thomas Gajewski, J. Richard Thistlethwaite, Kenneth Newell, and Maria-Luisa Alegre. NF-kB activation is necessary for cardiac allograft rejection. American Journal of Transplantation 2001; 1(Supplement 1): 269.

11. Zhong Guo, Jun Wang, L. Meng, Qiang Wu, Oliver Kim, J Hart, Gang He, Ping Zhou, JR Thistlethwaite, YangXin Fu, Maria-Luisa Alegre, Ken Newell. Membrane lymphotoxin regulates CD8+ T cell-mediated intestinal allograft rejection. Manuscript submitted.

12. Robert Chin, Ping Zhou, Maria-Luisa Alegre, Yang Xin Fu. Response to Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lumphoid tissue (Nature Medicine 6, 686-688,2000). Manuscript submitted.

Peer-reviewed conference presentations when In China

1. Ping Zhou, Suisheng Xia, Dungui Liu, et al. Experimental and clinical research on fetal kidney transplantation. The 1st Conference of Chinese Association of Transplantation, Wuhan, June1998.

2. Ping Zhou, Suisheng Xia, Dungui Liu, et al. CsA administration in adult recipients with fetal kidney grafts. The 2nd National Meeting on CsA, Guangzhou, August 1988.

3. Ping Zhou, Suisheng Xia, Shi Chen, et al. Heterotopic transplantation of multiple organs in dogs. The National Meeting of Chinese Association of Transplantation, Wuhan, 1990.

4. Ping Zhou, Fanjun Zeng, Dungui Liu, et al. Comparison of several multiorgan procurement techniques. The 2nd Meeting of Hubei Society of Transplantation, Yichang, April 1992.

5. Ping Zhou, Dungui Liu, Fanjun Zeng, et al. Experience in parenteral nutrition in 470 cases of renal transplantation. The 3rd National Meeting of Parenteral Nutrition, Nanjin, December 1992.

6. Ping Zhou, Suisheng Xia, Fanjun Zeng, Zhengbin Ling, et al. Experimental research on abdominal visceral cluster transplantation. The 12th Meeting of Chinese Association of Surgery, Wuhan, May 1993.

7. Ping Zhou, Hui Guo, Suisheng Xia, et al. Pathological studies on heterotopic multiple organ grafts in dogs. The 2nd National Meeting of Experimental Surgery, Wuhan, September 1992.

8. Suisheng Xia, Ping Zhou, Tao Wang, Hongchi Jong, Jinzhi Tang, et al. Living related spleen transplantation for the treatment of hemophilia A (5 cases report). The 2nd Conference of Chinese Association of Transplantation, Wuhan, October 1993.

9. Ping Zhou, Suisheng Xia, Dungui Liu, et al. Operative models and surgical techniques in abdominal multiple organ transplantation. The 2nd Conference of Chinese Association of Transplantation, Wuhan, October 1993.

10. Ping Zhou, Hua Wu, Fanjun Zeng. Experience in SPECT evaluation in renal transplantation. The 2nd Conference of Chinese Association of Transplantation, Wuhan, October 1993.

11. Ping Zhou, Fanjun Zeng, Zhengbin Lin, et al. Utilization and management of unideal kidney grafts. The 2nd Conference of Chinese Association of Transplantation, Wuhan, October 1993.

12. Ping Zhou, Fanjun Zeng, Dungui Liu, Suisheng Xia, et al. Prevention and management of perioperative complications in renal transplantation. The 2nd Conference of Chinese Association of Transplantation, Wuhan, October 1993.

13. Ping Zhou, Hua Wu, Fanjun Zeng, et al. SPECT evaluation on CsA nephrotoxicity in kidney transplant recipients. The 2nd National Meeting on Biological Science, Guangxi, December 1993.

14. Ping Zhou. Social problems and the influences of organ transplantation and the countermeasurements in China. The 1st Meeting of Hubei Society of Medical Sociology, Wuhan, July 1993.

15. Ping Zhou, Suisheng Xia, Dungui Liu, et al. A new operation for upper abdominal malignancies - abdominal cluster transplantation (1 case report). National Meeting on Malignancies in General Surgery, Haikou City, October 1994.

16. Ping Zhou, Dungui Liu, Suisheng Xia, et al. parenteral nutrition in liver transplantation. The 5th National Meeting on Parenteral and Enteral Nutrition, Kunming, April 1996.

17. Ping Zhou, Dungui Liu, Suisheng Xia, et al. Parenteral nutrition in the transplantation of large solid abdominal organs. The 4th Meeting of Hubei Society of Surgery and Transplantation, 1996.

18. Ping Zhou, Dungui Liu, Fanjun Zeng. Diagnosis and treatment of acute abdomen in renal transplant recipients. . The 4th Meeting of Hubei Society of Surgery and Transplantation, 1996.

19. Ping Zhou, Fanjun Zeng, Dungui Liu, et al. Diagnosis and treatment of upper urinary tract obstruction of renal grafts. 1995 National Meeting on Organ Transplantation, Guangzhou, October 1995.

20. Ping Zhou, Dungui Liu, Suisheng Xia, et al. Quaternary therapy for acute pancreatitis. The 2nd National Meeting on Basic and Clinical Research in General Surgery, August 1995.

21. Ping Zhou, Fanjun Zeng, Dungui Liu, et al. Diagnosis and treatment of abdominal surgical complications in renal transplant recipients. The 4th Meeting of Hubei Society of Surgery and Transplantation, 1996.

22. Ping Zhou, Fanjun Zeng. Diagnosis and treatment of graft rupture in renal transplant recipients. The 4th Meeting of Hubei Society of Surgery and Transplantation, 1996.

23. Ping Zhou, Dungui Liu. Significance of octreotide and TPN in the treatment of acute pancreatitis. The 4th Meeting of Hubei Society of Surgery and Transplantation, 1996.

Peer-reviewed conference presentations when in America

All these presentations were given orally. In academic scientific meetings, top papers are selected for oral presentation, as time is usually too limited to present all papers orally. The remaining papers are presented as posters. My presentations have always been received enthusiastically are have led to many questions and discussion.

1. Ping Zhou, Gregory L. Szot, Jeffrey Bluestone, Richard Thistlethwaite, et al. Murine allogeneic heart graft rejection is dependent on indirect B7 mediated costimulation. Oral presentation at ASTS (American Society of Transplant Surgeons) 1999 Annual Meeting.

2. Ping Zhou, Gregory L. Szot, Richard Thistlethwaite, Jeffrey Bluestone, Marisa Alegre, et al. Signaling through STAT4 or STAT6 is not required for acute allograft rejection or for the induction of tolerance by CTLA4-Ig treatment in a murine cardiac transplant model. Oral presentation at ASTS (American Society of Transplant Surgeons) 2000 Annual Meeting, Chicago and XVIII International Congress of Transplantation Society 2000, Rome, Italy.

3. Greg L. Szot, Ping Zhou, Christine Guo, Kenneth A. Newell, J. Richard Thistlethwaite, Jeffrey A. Bluestone, Maria-Luisa Alegre. Role of CD8+ T cells in cardiac allograft rejection in wild-type and CD28-deficient mice. Oral presentation at AST and ASTS Combined Annual Meeting 2000, Chicago.

4. Jeffrey Bluestone, Kyung-Mi Lee, Maria-Luisa Alegre, Matthew Griffin, Benoit Solomon, Greg Szot, Ping Zhou, William Sweatt. Immune regulation through CD28/B7 interactions. Oral presentation at XVIII International Congress of Transplantation Society 2000, Rome, Italy.

5. Ping Zhou, Kwang Woo Hwang, Jun Wang, Christine Guo, Mary Markiewicz, Oliver Kim, Thomas Gajewski, J. Richard Thistlethwaite, Kenneth Newell, and Maria-Luisa Alegre. The role of NF-kB activation in allograft rejection. Oral presentation at ASTS (American Society of Transplant Surgeons) Transplant 2001 Meeting, Chicago.

6. M-L. Alegre, G.L. Szot, Ping Zhou, I. Rulifson, J. Wang, Z. Guo, O. Kim, K.A. Newell, J. Richard Thistlethwaite, and J.A. Bluestone. T Cell Subsets and CD28 Signals in Cardiac Allograft Rejection. AAI (American Association of Immunologists) Annual Meeting, March 31 - April 4, 2001. Orlando, FL.

Citation of my publications

Most of my papers are about hottest researches in transplantation and transplant immunology. For the papers I published in China, I have no means to check the citation of my papers right now. For the papers published in America, some are too new to be recorded by some information institute. Some of my papers can be checked out. It is an honor that two of my papers were cited three times by the articles published in one of the most prestigious medical journal, Nature Medicine. Here below are the reports on the cited-by information for some of my papers published in America, recorded in ISI (Institute for Scientific Information) Web of Science (http://webofscience.com/CIW.cgi):

1. Absence of host B7 expression is sufficient for long-term murine vascularized heart allograft survival.
Zhou Ping, Szot GL, Sharpe AH, He G, Kim O, Newell KA, Bluestone JA, Thistlethwaite JR.
TRANSPLANTATION. 69 (5): 904-909 MAR 15 2000 [Published erratum correction on authorship appears in Transplantation August 27, 2000, Vol.70(5), 707]

Document type: Article
Language: English
Times Cited: 6

The article above is cited by following 6 articles:

ˇ Kirk AD, Tadaki DK, Celniker A, et al. Induction therapy with monoclonal antibodies specific for CD80 and CD86 delays the onset of acute renal allograft rejection in non-human primates. TRANSPLANTATION 72 (3): 377-384 AUG 15 2001.

ˇ Maier S, Tertilt C, Chambron N, et al. Inhibition of natural killer cells results in acceptance of cardiac allografts in CD28(-/-) mice. NAT MED (Nature Medicine) 7 (5): 557-562 MAY 2001.

ˇ Salomon B, Bluestone JA. Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. ANNU REV IMMUNOL 19: 225-252 2001.

ˇ Alegre M, Fallarino F, Zhou P, et al. Transplantation and the CD28/CTLA4/B7 pathway. TRANSPLANT P 33 (1-2): 209-211 FEB-MAR 2001.

ˇ Szot GL, Zhou P, Bluestone, et al. Absence of host B7 expression is sufficient for long-term murine vascularized heart allograft survival (vol 69, pg 904, 2000). TRANSPLANTATION 70 (4): 707-707 AUG 27 2000.

ˇ Salomon B, Lenschow DJ, Rhee L, et al. B7/CD28 costimulation is essential for the homeostasis of the CD4(+)CD25(+) immunoregulatory T cells that control autoimmune diabetes. IMMUNITY 12 (4): 431-440 APR 2000.

2. Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance.
Zhou Ping, Szot GL, Guo Z, Kim O, He G, Wang J, Grusby MJ, Newell KA, Thistlethwaite JR, Bluestone JA, Alegre ML.
JOURNAL OF IMMUNOLOGY. 165 (10): 5580-5587 NOV 15 2000

Document type: Article
Language: English
Times Cited: 3

The article above is cited by following 3 articles:

ˇ Gorczynski RM. Role of cytokines in allograft rejection. CURR PHARM DESIGN 7 (11): 1039-1057 JUL 2001

ˇ Takatsuki M, Uemoto S, Inomata Y, et al. Analysis of alloreactivity and intragraft cytokine profiles in living donor liver transplant recipients with graft acceptance. TRANSPL IMMUNOL 8 (4): 279-286 FEB 2001

ˇ Alegre M, Fallarino F, Zhou P, et al. Transplantation and the CD28/CTLA4/B7 pathway. TRANSPLANT P 33 (1-2): 209-211 FEB-MAR 2001

3. Cutting edge: Blockade of the CD28/B7 costimulatory pathway inhibits intestinal allograft rejection mediated by CD4(+) but not CD8(+) T cells
Newell KA, He G, Guo Z, Kim O, Szot GL, Rulifson I, Zhou P, Hart J, Thistlethwaite JR, Bluestone JA
JOURNAL OF IMMUNOLOGY. 163 (5): 2358-2362 SEP 1 1999

Document type: Article
Language: English
Times Cited: 22

The article above is cited by following 22 articles:

ˇ Maier S, Tertilt C, Chambron N, et al. Inhibition of natural killer cells results in acceptance of cardiac allografts in CD28(-/-) mice. NAT MED (Nature Medicine) 7 (5): 557-562 MAY 2001.

ˇ Laning JC, DeLuca JE, Isaacs CM, et al. In vitro analysis of CD40-CD154 and CD28-CD80/86 interactions in the primary T-cell response to allogeneic "nonprofessional" antigen presenting cells. TRANSPLANTATION. 71 (10): 1467-1474 MAY 27 2001.

ˇ Guo Z, Meng LZ, Kim O, et al. Cd8 T cell-mediated rejection of intestinal allografts is resistant to inhibition of the CD40/CD154 costimulatory pathway. TRANSPLANTATION 71 (9): 1351-1354 MAY 15 2001.

ˇ Reddy B, Gupta S, Chuzhin Y, et al. The effect of CD28/B7 blockade on alloreactive T and B cells after liver cell transplantation. TRANSPLANTATION 71 (6): 801-811 MAR 27 2001 .

ˇ Alegre M, Fallarino F, Zhou P, et al. Transplantation and the CD28/CTLA4/B7 pathway. TRANSPLANT P 33 (1-2): 209-211 FEB-MAR 2001.

ˇ Meng L, Guo Z, Kim O, et al. Blockade of the CD40 pathway fails to prevent CD8 T cell-mediated intestinal allograft rejection. TRANSPLANT P 33 (1-2): 418-420 FEB-MAR 2001.

ˇ Trambley J, Lin A, Elwood E, et al. FasL is important in costimulation blockade-resistant skin graft rejection. TRANSPLANTATION 71 (4): 537-543 FEB 27 2001.

ˇ Ito H, Kurtz J, Shaffer J, et al. CD4 T cell-mediated alloresistance to fully MHC-mismatched allogeneic bone marrow engraftment is dependent on CD40-CD40 ligand interactions, and lasting T cell tolerance is induced by bone marrow transplantation with initial blockade of this pathway. J IMMUNOL 166 (5): 2970-2981 MAR 1 2001.

ˇ Bishop DK, Wood SC, Eichwald EJ, et al. Immunobiology of allograft rejection in the absence of IFN-gamma: CD8(+) effector cells develop independently of CD4(+) cells and CD40-CD40 ligand interactions
ˇ J IMMUNOL 166 (5): 3248-3255 MAR 1 2001.

ˇ Bumgardner GL, Gao DH, Li JS, et al. Rejection responses to allogeneic hepatocytes by reconstituted scid mice, CD4 KO, and CD8 KO mice. TRANSPLANTATION 70 (12): 1771-1780 DEC 27 2000.

ˇ Rothstein DM, Livak MFA, Kishimoto K, et al. Targeting signal 1 through CD45RB synergizes with CD40 ligand blockade and promotes long term engraftment and tolerance in stringent transplant models. J IMMUNOL 166 (1): 322-329 JAN 1 2001.

ˇ Williams MA, Trambley J, Ha J, et al. Genetic characterization of strain differences in the ability to mediate CD40/CD28-independent rejection of skin allografts. J IMMUNOL 165 (12): 6849-6857 DEC 15 2000.

ˇ Morelli AE, Thomson AW. Role of dendritic cells in the immune response against allografts. CURR OPIN NEPHROL HY 9 (6): 607-613 NOV 2000.

ˇ Gaglia JL, Greenfield EA, Mattoo A, et al. Intercellular adhesion molecule 1 is critical for activation of CD28-deficient T cells. J IMMUNOL 165 (11): 6091-6098 DEC 1 2000.

ˇ Zhou P, Szot GL, Guo Z, et al. Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance. J IMMUNOL 165 (10): 5580-5587 NOV 15 2000.

ˇ Gao DH, Li JS, Orosz CG, et al. Different costimulation signals used by CD4(+) and CD8(+) cells that independently initiate rejection of allogenic hepatocytes in mice. HEPATOLOGY 32 (5): 1018-1028 NOV 2000.

ˇ Takayama T, Morelli AE, Robbins PD, et al. Feasibility of CTLA4lg gene delivery and expression in vivo using retrovirally transduced myeloid dendritic cells that induce alloantigen-specific T cell anergy in vitro. GENE THER 7 (15): 1265-1273 AUG 2000.

ˇ Jones ND, Van Maurik A, Hara M, et al. CD40-CD40 ligand-independent activation of CD8(+) T cells can trigger allograft rejection. J IMMUNOL 165 (2): 1111-1118 JUL 15 2000.

ˇ Kishimoto K, Dong VM, Issazadeh S, et al. The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo. J CLIN INVEST 106 (1): 63-72 JUL 2000.

ˇ Griffin MD, Lutz WH, Phan VA, et al. Potent inhibition of dendritic cell differentiation and maturation by vitamin D analogs. BIOCHEM BIOPH RES CO 270 (3): 701-708 APR 21 2000.

ˇ Li YS, Strom TB. Failure of combined costimulatory blockade in animal transplant model - Reply. NAT MED (Nature Medicine) 6 (2): 115-115 FEB 2000.

ˇ Trambley J, Bingaman AW, Lin A, et al. Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection. J CNILI INVEST 104(12):1715-1722 DEC 1999.

(All supporting data are available in request.)

1/1/2002