Ben johnson steroids
Recently studies have shown that 19-nortestosterone is endogenously produced in other mammals besides the horse. ben johnson steroids Anabolic-steroids-online. 19-norandrostenedione was first isolated from ovarian follicular fluid of horses by R. Short in 1960. 1 Recently the presence of 19- norandrostenedione has been found as a major steroid in porcine ovarian follicular fluid,2 with 19-nortestosterone as a minor component4. ben johnson steroids Legal-anabolic-steroids. In the two previous studies it was found that the levels of both compounds were highest in preovulatory and large follicles. 19-nortestosterone was also reported as a minor component in horse ovarian follicular fluid,5 horse testis and pig testis. 6There is one report of the formation of 19- nortestosterone and 19-norandrostenedine from testosterone by baboon placental microsomes. ben johnson steroids Steroids in sports. 7 There is also another report that 19- nortestosterone can be formed from testosterone by mouse kidney slices. 8Nevertheless, there is still no evidence that 19- nortestosterone is produced endogenously in man - at least not in concentrations that are detectable by present analytical means. Many studies including two recent ones done in the U. S. 9 and U. K. 10, have shown that the hydroxylations, oxidation and decarboxylation processes involving testosterone and leading to estrogens, occur at the same or adjacent enzymatic sites, with the intermediates remaining on the enzymes. Any intermediates, such as 19- nortestosterone, would therefore be very short lived and likely would not accumulate in any appreciable concentrations. Thus it seems that the rapid conversion of 19- nortestosterone prior to tissue distribution and excretion, normally does not allow its detection in body tissues or fluids. I feel that it is logical to assume that 19- nortestosterone is in fact produced as an intermediate compound in humans but that normally no accumulation of the compound occurs due to the rapidity of the aromatization process. Or if there is an accumulation then it is likely in amounts which are below the present detection limit, which is about 0. 25 nanograms/milliliter of urine for most steroids. At present most laboratories consider a trace to be 2 to 5 times the stated detection limit depending on the compound and the medium being tested. It is not known, however, if significant accumulation or excretion occurs under certain physiological or pathological conditions. The dynamics of the system may be such that under conditions where the normal metabolic pathways are disrupted by the presence of exogenous anabolic steroids or by the previous use of exogenous 19- nortestosterone, the aromatization process may be affected in such a way so as to allow significant accumulation and excretion of some 19-norsteroids - perhaps enough to be detected by today's sensitive techniques. Thus it is possible that the use of other anabolic steroids can increase the formation of the 19- norsteroids by altering the metabolic transformation of testosterone to estrogen. It is a well known fact that many of the enzymes in the liver and other organs can be increased or decreased by treatment with certain drugs and hormones. This shifting in the enzyme levels can alter the rate of metabolite production of certain intermediate hormones by altering the dynamics of the testosterone-estrogen metabolic pathways - possibly allowing the accumulation (and subsequent tissue excretion) of compounds which under normal circumstances would not accumulate. Increased or reduced activity of one or more of the intracellular enzymes involved in transformation of testosterone to estrogen might lead to intracellular and extracellular accumulation of immediate or remote precursors of those enzymatic reactions. There is, therefore the possibility of a hormonally induced rise in the production of 19-nortestosterone and its metabolites. Also it is well known that the end product of a reaction sequence often regulates the activity of other enzymes in a biosynthetic pathway. It is feasible, therefore, that the use of aromatizing anabolic steroids may inhibit one or more of the enzymes involved in the transformation of testosterone (or androstenedione) to estrogen. This end product inhibition may result in product excess (possibly 19-nortestosterone). The reduced activity of one of the intracellular enzymes can lead to the intracellular and extracellular accumulation of an immediate or remote precursor somewhere along the metabolic chain. It must still be remembered, however, that there is considerable variation in the metabolites formed from one species to another and from one tissue to another. No one as yet has identified these 19-norsteroids as naturally occurring in the human. The Previous Use of 19-nortestosteroneThe use of exogenous 19-nortestosterone may stimulate the synthesis of certain enzymes and inhibit the synthesis of others so that the end result may be an accumulation and excretion of 19- nortestosterone and its three metabolites as well as the formation of estrogenic compounds. Even after the exogenous 19-nortestosterone is stopped the enzymatic processes may be sufficiently altered so that the athlete may continue to accumulate 19-nortestosterone and therefore continue to show a positive urine test long after the last traces of the exogenous 19- nortestosterone have been excreted. Thus increased enzyme activity forming 19-norsteroids rather than estrogens, might be induced by the exogenous use of 19-nortestosterone. The accumulation and excretion of 19- nortestosterone and its metabolites may further be enhanced by the use of other anabolic steroids as explained above. It's also possible that the use of other drugs such as the anti-estrogens, by similarly affecting the enzymatic pathway of estrogen production, may increase endogenous production and accumulation of 19-nortestosterone. Formation of 19-nortestosterone During the Chromatographic Purification19-norsteroids are easily formed from 19-oxo androstenedione and 19-oxo testosterone in basic methanol (MEOH/OH-).
Ben johnson steroids
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