Anabolic steroids sports
His research showed that when the dose of nandrolone was divided into frequent small injections in such a pattern as to mimic the pharmacokinetics of esters, the anabolic effect became identical to that of the esters. anabolic steroids sports Controversial-on-steroids. Thus, pharmacokinetics, the log dose/response curve, and differences in molecular weight are sufficient to account for observed differences in anabolic effect between different esters of an anabolic steroid, or between an ester and the parent drug. This correlates with my observation that anabolic effect of testosterone esters is equal, so long as each is administered reasonably frequently: at least once per half-life, and preferably twice. E. anabolic steroids sports Steroid-side-effects. g. , if testosterone propionate yielding some given amount of testosterone per week is administered daily, or at least every other day, it will give results comparable to testosterone cypionate administered at least once every week, and preferably twice per week, that yields the same amount of testosterone per week. How can the differences in anabolic/androgenic ratio be accounted for, and how significant are they?Partition coefficient is key information for determining how a drug will be distributed in the body. anabolic steroids sports Controversial-on-steroids. The ratio of solubility between oil and water gives good relative predictions of the ratios of solubility between blood and target organs. Different target organs, for example the levator ani muscle vs. the prostate, may have different solubility properties. A more lipophilic drug (one with a high partition coefficient) would distribute much moreso into a more lipophilic target organ than into a less lipophilic one. It may then be the case that the longer chain esters partition more preferentially into muscle and less preferentially into the skin and prostate, but this is not demonstrated. For this to be the case, it would be necessary for the esterified steroids to be distributed throughout the body after slow release from the oil depot injection site, rather than to have only free parent drug released from the injection site. This is an agreement with the findings of James et al. 3 which demonstrate that the esters do indeed become distributed throughout the body after injection. I don't, however, expect that differences in distribution are the primary reason for observed differences in anabolic/androgenic ratio between different steroid esters. There is another possible explanation for differences in this ratio. In the same work referenced above concerning anabolic effect as a function of pharmacokinetics, van der Vies showed that if nandrolone is administrated with frequent dosage patterns designed to give the same trend of serum levels as seen with either phenylpropionate or decanoate, nandrolone itself gave the same anabolic/androgenic ratios as each of these esters of nandrolone. What application does this information on anabolic/androgenic ratio have to female bodybuilding?Since keeping androgen levels constant and moderate gives a higher anabolic/androgenic ratio than using the same total amount of drug per week but allowing levels to spike and then subside, female bodybuilders are better advised to use either long acting esters, or if short acting esters are used, to inject small doses frequently (twice per half-life). And for the same reason, a given amount of oral steroids per day is better taken in divided doses than in a single larger dose. This is probably because tissues with sex-specific traits exhibit thresholds to effect of androgens. Below the threshold, nothing happens, but above it, cellular differentiation occurs. Thus, while female levels of androgens are about 10% that of a male's, 10 years of female levels of androgen will not grow as much beard or change the voice as much as one month of male levels. The threshold simply is not crossed at the lower levels, but is crossed at the higher levels. Female bodybuilders will do better to avoid spikes in androgen level that cross this threshold. Therefore, consistent low doses are better than spiking with intermittent high doses, and advice to use 100 mg/week of testosterone propionate to avoid virilization simply makes no sense (and in practice, often fails. )It should still be noted that some women will suffer virilization with almost any dose of anabolic steroid, regardless of dosing pattern. What are the half-lives of different esters?Shorter chain esters have shorter half-lives, because of their lower partition coefficient. Testosterone cypionate has a half-life of 8 days5, the enanthate ester has a half-life of 4 days6, and nandrolone decanoate has a half-life of 8 days7. These figures are only approximate.
Anabolic steroids sports
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