Clark receives a prophetic phone call from Lana. Adam escapes and Lionel reveals a shocking secret.

What's up with Clark: Pete and Clark volunteer at a crisis hotline at the Smallville community center. When Clark answers a call, he hears a frantic Lana on the line. She tells him "it's happening" and begs him to help her. Clark hears a gunshot and Lana falls to the ground. Clark runs to the Talon, but when he arrives, he finds Lana, alive and well, studying with Chloe. The sheriff thinks it's just a prank call, but Clark and Lana disagree. While listening to a recording of the call, Clark's super hearing picks up Adam's voice. He uses a computer program to isolate it and plays it for Chloe and Lana. The three then also hear a radio in the background; it's broadcasting a basketball game that won't be played until later that night.

What's up with Lex: Lex brings a vile of the platelets to Lionel and tells him he knows about the lab and the research. He threatens to release the information to the press, but he tells Lionel he doesn't want the research shut down, he wants to be put in charge of it.

What's up with Adam: Lionel heads to the lab and tells Dr. Teng that everything must be moved immediately. When he leaves she tells Adam that Lionel took all the serum and she can't take him with her. Without the serum he only has 12 hours to live. Later, Clark tells Lex he knows about Lex's involvement with the lab and that in order to save Lana they must find Adam. When the two arrive, the lab is in shambles, and all the lab technicians along with Dr. Teng are dead. Adam is gone!

What's up with Lana: Events are starting to unfold. The basketball game starts, the storm that was heard over the phone has arrived, and Lana is scared. Clark tells her she'll be safe at the farm and she waits there with Mr. Kent.

How it ends: Clark and Lex are about to continue their search for Adam when Metropolis detectives show up at the mansion and hold them for questioning. Lex is being set up for the murders at the lab. Adam takes Chloe hostage and learns that Lana's at the farm. When they pull up, he knocks out Mr. Kent and grabs Lana. He takes her to the storage facility where she locked up the things he left in his apartment, but the serum he had is gone. When he turns his anger towards Lana, she's able to knock him down and run off.

Meanwhile, Clark is finally allowed to leave the mansion. He heads to the crisis hotline after talking to a dazed Jonathan and Chloe. As she runs from Adam, Lana calls Clark. While they're on the phone, a bolt of lightning hits the telephone poll causing it to crash on some small pieces of meteor rock... the phone goes dead. Clark rushes out side and lifts the poll, the separation from the rock restores the call and Clark is able to hear where Lana is, he rushes off just as Adam shoots. Adam watches as Clark dashes in front of Lana and takes the bullet. Lana is knocked down and doesn't see it happen. When Clark gets to Adam, he's dying and tells Clark what he saw and that he now knows why Lionel is so interested in him. Before he dies, Adam warns Clark about Lionel, saying he won't be able to escape him forever.

The detectives are arresting Lex when the FBI shows up. Lex tells them he'll cut them a deal. Give him immunity and he'll help them take down Lionel. While the FBI mauls over the decision, Lionel talks with Dr. Bergin and tells him he wants him to continue the serum research. Bergin tells him it will take time... Lionel doesn't have time; he's been diagnosed with a unique liver disease and is running out of time. Later that night Lionel listens to opera music and reads his medical report. His disease is terminal... After reading the report, Lionel grabs a gun and points it at his head...