| Robert Crumb | Himself |
| Aline Kominsky | Herself (Robert Crumb's wife) |
| Charles Crumb | Himself (R. Crumb's older brother) |
| Maxon Crumb | Himself (R. Crumb's younger brother) |
| Robert Hughes | Himself (art critic) |
| Martin Muller | Himself (owner, Modernism Gallery) |
| Don Donahue | Himself (publisher, Zap Comix) |
| Dana Crumb | Herself (R. Crumb's first wife) |
| Trina Robbins | Herself (cartoonist) |
| Spain Rodriguez | Himself (cartoonist) |
| Deirdre English | Herself (former editor, Mother Jones) |
| Peggy Orenstein | Herself (journalist) |
| Beatrice Crumb | Herself (R. Crumb's mother) |
| Kathy Goodell | Herself (R. Crumb's ex-girlfriend) |
| Dian Hanson | Herself (editor, Leg Magazine; former girlfriend) |
| Sophie Crumb | Herself (R. Crumb's & Aline's daughter) |
| Jesse Crumb | Himself (R. Crumb's and Dana's son) |
| Bill Griffith | Himself (cartoonist) |
