In humans, the onset of gastrointestinal upset for many non-steroid anti-inflammatory drugs is generally within the first 2-6 hours after ingestion, with the onset of gastrointestinal hemorrhage and ulceration occurring 12 hours to 4 days post ingestion. The onset of renal failure, in humans, often occurs within the first 12 hours after massive exposure to NSAID, but may be delayed up to 3-5 days post exposure.

Acetaminophen toxicity may result from a single toxic dose, or from repeated ingestion of large doses of acetaminophen. When the liver and kidneys are not supported and kept clean, the body begins to store toxins in the tissue with any number of damaging symptoms resulting.

 Hepatotoxicity can result from acute overdoses or from chronic use (i.e., several months of daily administration). Tylenol side effects include: light headedness, dizziness, drowsiness, and slurred speech. 

The liver-kidney-heart muscle toxicities associated with analgesic drugs have not been reported by most media sources. Further findings suggest that pain in the upper abdomen, hypoglycemia, encephalopathy, abnormal functioning of brain tissue, and kidney failure may become apparent as bloodtoxicity increases. 

 Acetaminophen, while generally safe for short-term use, can cause problems with long-term administration. These problems include liver and kidney damage and gastrointestinal bleeding.   Acetaminophen Poisoning - Print Version: Online Reference For ...   Print Version) Anelgesic Toxicity - Disease Therapy Protocol

Acetaminophen  is used to relieve many kinds of minor aches and pains. Long term use may result in  acetaminophen-induced toxicity.