Chapter 12

1. Describe the structural organization of the genome.
2. Overview the major events of cell division that enable the genome of one cell to be passed on to two daughter cells.
3. Describe how chromosome number changes throughout the human life cycle.
4. List the phases of the cell cycle and describe the sequence of events that occurs during each phase.
5. List the phases of mitosis and describe the events characteristic of each phase.
6. Recognize the phases of mitosis from diagrams or micrographs.
7. Draw or describe the spindle apparatus including centrosomes, nonkinetochore microtubules, kinetochore microtubules, asters, and centrioles (in animal cells).
8. Describe what characteristic changes occur in the spindle apparatus during each phase of mitosis.
9. Explain the current models for poleward chromosomal movement and elongation of the cell's polar axis.
10. Compare cytokinesis in animals and plants.
11. Describe the process of binary fission in bacteria and how this process may have evolved to mitosis in eukaryotes.
12. Describe the roles of checkpoints, cyclin, Cdk, and MPF, in the cell-cycle control system.
13. Describe the internal and external factors which influence the cell-cycle control system.
14. Explain how abnormal cell division of cancerous cells differs from normal cell division.