Psychotherapeutic alternatives to pharmacotherapy exist and are widely used, ranging from cognitive, behavioral, cognitive-behavioral, or supportive non-directive therapy to anxiety management and various types of relaxation training. The evidence of the efficacy of these numerous approaches in treatment of GAD exists, but is scarce and often contradictory. It is especially the long-term follow-up studies, few of which are available, and those which are usually lack a waiting-list control group because of ethical reasons.

The situation is further complicated by the fragility of the construct of GAD as a diagnostic entity, topic that has generated a heated debate and an unstoppable stream of changes of diagnostic criteria in every new edition of DSM, starting by the DSM-III (APA, 1987, 1994) thus rapidly outdating past research. Nevertheless, clinicians faced with a suffering candidate for the GAD diagnosis can hardly indulge themselves in a debate whether the patient's condition does or does not theoretically exist, they have to provide the best treatment to their knowledge. The bottom line is that most of the above mentioned treatments produce alleviation of anxiety symptoms, the difference lies in their potency to reduce acute anxiety and to sustain the improvement.