Sakura Tomoyo is obviously totally devoted to Sakura. They are a pair of close best friends that cares for each other. Sakura has a tendency to be really naive at obvious things; and Tomoyo is always there helping her out.

Syaoran They're not really close, but Tomoyo loves to pop out here and there to talk about Sakura to Syaoran. It seems that Syaoran trusts Tomoyo as he takes her advices.

Eriol Tomoyo sees Eriol as 'someone looking out for Sakura and her safety', and also as friends. They both share a lot of same qualities, like both are calm, have same hair color and; the most important one is they look out for others.

Mei Ling They don't really talk to each other but it seems that their relationship is civil.

Touya Touya is known as 'Sakura's brother' to Tomoyo, nothing else. I think.

Yukito Tomoyo is just known to Yukito as 'Sakura's best friend'. I don't think they ever spoke to one another.

Sonomi Being Sonomi's child and all; Tomoyo was forced to go through childhood as a duplica of Nadeshiko. But Tomoyo doesn't seem to mind. The truth is that Sonomi cares for Tomoyo as any mother would.

Kero-chan Kero-chan loves to have Tomoyo around; because Tomoyo brings lots of delicious food and Kero-chan is able to act out his 'macho' side to Tomoyo's camera.