| Item | Price | Location | Description |
| Antidote | 100Ľ | Pokémon Mart | Cures Poison Status |
| Awakening | 250Ľ | Pokémon Mart | Wakes up a sleeping pokémon |
| Bicycle | 1 millionĽ | Cerulean City | Allows faster movement |
| Bike Voucher | free | Vermillion City | Allows free purchase of Bicycle. |
| Burn Heal | 250Ľ | Pokémon Mart | Cures Burn Status |
| Calcium | 9,800Ľ | Celadon City | Boosts Special Rating for one pokémon |
| Carbos | 9,800Ľ | Celadon City | Boosts Speed Rating for one pokémon |
| Card Key | free | Saffron City-Silph co. | Opens Silph co. locked doors |
| Coin | free | Celadon City | Allows use of slot machines |
| Coin Case | free | Celadon City | Carries coins |
| Dire Hit | 650Ľ | Celadon City | Boosts Pokémon's Attack |
| Dome Fossil | Defeat Specific Trainer | Mt. Moon | Clones KABUTO at the Pokémon Lab, Cinnibar Island |
| Elixer | free | Found in several areas | Adds 10PP to all moves of one pokémon |
| Escape Rope | 550Ľ | Pokémon Mart | Lets you escape from a cavern |
| Ether | free | Found in several areas | Adds 10PP to one ability |
| Exp. All | Have 50 differant pokémon | Route#15/Fuchsia City | Shares exp. gained from battles |
| Fire Stone | 2,100Ľ | Celadon City | Triggers evolution on certain pokémon |
| Fresh Water | 200Ľ | Celadon City | Quenches police officer's thirst, Restores 50HP |
| Full Heal | 600Ľ | Pokémon Mart | Cures any status(PSN,BRN,FRZ,ect.) |
| Full Restore | 3,000Ľ | Pokémon Mart | Cures pokémon's status and restores all HP |
| Gold Teeth | free | Fuchsia City-Safari Zone | Aids the Warden to speek |
| Good Rod | free | Fuchsia City | Allows you to fish for good pokémon |
| Great Ball | 600Ľ | Pokémon Mart | Used to catch pokémon |
| Guard Spec. | 700Ľ | Celadon City | Disables special attacks |
| Helix Fossil | Defeat Specific Trainer | Mt. Moon | Clones OMANYTE at the Pokémon Lab, Cinnibar Island |
| HP Up | free | Found in several areas | Increases MaxHP of a pokémon by one point |
| Hyper Potion | 1,500Ľ | Pokémon Mart | Restores 200HP |
| Ice Heal | 250Ľ | Pokémon Mart | Cures Frozen Status |
| Iron | 9,800Ľ | Celadon City | Boosts Defence rating for one pokémon |
| Item Finder | Have 30 differant pokémon | Route#11/Route#12 | Reveals hidden items with a tone |
| Leaf Stone | 2,100Ľ | Celadon City | Triggers evolution on certain pokémon |
| Lemonade | 350Ľ | Celadon City | Quenches police officer's thirst, Restores 80HP |
| Lift Key | Defeat Specific Trainer | Celadon City-Team Rocket Hq. | Allows use of elevater |
| Master Ball | Rescue President | Saffron City-Silph co. | Used to catch pokémon, ALWAYS works |
| Max Elixer | free | Found in several areas | Restores all the PP of one pokémon |
| Max Ether | free | Found in several areas | Restores all the PP of one ability |
| Max Potion | 2,500Ľ | Pokémon Mart | Restores all HP for one pokémon |
| Max Repel | 700Ľ | Pokémon Mart | Prevents wild pokémon attacks |
| Max Revive | free | Found in several areas | Brings a pokémon back to life at full HP |
| Moon Stone | free | Found in several areas | Triggers evolution on certain pokémon |
| Nugget | free | Found in several areas | Can be sold for lots of money |
| Oak's Parcel | free | Viridian City | Bring the parcel to Prof. Oak, because it's his |
| Old Amber | Requires CUT | Pewter City's Museum | Clones AERODACTYL at the Pokémon Lab |
| Old Rod | free | Vermillion City | Allows you to fish for old pokémon |
| Paralyze Heal | 200Ľ | Pokémon Mart | Cures Paralyze Status |
| Poké Ball | 200Ľ | Pokémon Mart | Used to catch pokémon |
| Poké Doll | 1,000Ľ | Celadon City | Distracts opponent, give to girl in Saffron City |
| Poké Flute | Beat Pokémon Tower | Lavender Town | Wakes up sleeping pokémon |
| Pokédex | Return Oak's Parcel | Pallet Town | Stores pokémon data when you catch them |
| Potion | 300Ľ | Pokémon Mart | Restores 20HP |
| PP Up | free | Found in several areas | Boosts PP of one attack by one point |
| Protein | 9,800Ľ | Celadon City | Boosts Attack Rating for one pokémon |
| Rare Candy | free | Found in several areas | Increases pokémon's Experience level by one |
| Repel | 350Ľ | Pokémon Mart | Prevents wild pokémon attacks |
| Revive | 1,500Ľ | Pokémon Mart | Revives fainted pokémon |
| S.S. Ticket | Help Bill | Sea Cottage | Allows you to enter the S.S. Anne |
| Safari Ball | 500Ľ/30 | Fuchsia City-Safari Zone | Used in Safari Zone to catch pokémon |
| Secret Key | free | Cinnibar Island | Opens locked door to the Volcano Gym |
| Silph Scope | Defeat Specific Trainer | Celadon City-Team Rocket Hq. | Used to ID ghosts |
| Soda Pop | 300Ľ | Celadon City | Quenches police officer's thirst, Restores 60HP |
| Super Potion | 700Ľ | Pokémon Mart | Restores 50HP |
| Super Repel | 500Ľ | Pokémon Mart | Prevents wild pokémon attacks |
| Super Rod | free | Route#12 | Allows you to fish for super pokémon |
| Thunder Stone | 2,100Ľ | Celadon City | Triggers evolution on certain pokémon |
| Town Map | free | Pallet Town | Use to look at the map of Pokémon Island |
| Ultra Ball | 1,200Ľ | Pokémon Mart | Used to catch pokémon |
| Water Stone | 2,100Ľ | Celadon City | Triggers evolution on certain pokémon |
| X Accuracy | 950Ľ | Celadon City | Increases Accuracy for one battle |
| X Attack | 500Ľ | Celadon City | Increases Attack for one battle |
| X Defend | 550Ľ | Celadon City | Increases Defense for one battle |
| X Special | 350Ľ | Celadon City | Increases Special for one battle | X Speed | 350Ľ | Celadon City | Increases Speed for one battle |