Tennessee State Route 43 runs north-south in Eastern Obion County. It runs un-signed along U.S. Rt. 45E for most of it's time in the county. TN St Rt 43 does not pass through any towns in Obion County. TN St Rt 43 is multi-plexed in Obion County. U.S. Rt. 45E, from near South Fulton to the Obion/Weakly County Line. TN St Rt 43 intersects the following highways in Obion County. U.S. Rt. 45E, near South Fulton.
Tennessee State Route 215, near South Fulton. Tennessee State Route 190, near Mc Connell.
