U.S. Federal Route 45 is a short highway in Northern Obion County. This runs from the Kentucky/Tennessee State Line south to a junction with U.S. Rt. 51/45W/45E. U.S. Rt. 45 does not pass through any towns in Obion County. U.S. Rt. 45 is multi-plexed in Obion County. U.S. Rt. 51, near South Fulton. U.S. Rt. 45 intersects the following highways in Obion County. U.S. Rt. 45E, near South Fulton. U.S. Rt. 45W, near South Fulton. U.S. Rt. 51, near South Fulton.