U.S. Federal Route 61 runs north-south in Southwestern Tennessee. It only runs in Shelby County. It enters the state with Interstate 55 from Arkansas and head south along Third Street. U.S. Rt. 61 uses Third Street and heads south into Mississippi. U.S. Rt. 61 passes through the following town in Shelby County. Memphis
SB I-55/U.S. Rt. 61; EB U.S. Rt. 64-70; NB U.S. Rt. 79 crossing the Mississippi River. NB I-55/U.S. Rt. 61; WB U.S. Rt. 64-70; SB U.S. Rt. 79 on the Tennessee side of the Mississippi River bridge. SB I-55/U.S. Rt. 61; EB U.S. Rt. 64-70; NB U.S. Rt. 79 at the Tennessee Welcome sign. A BGS on SB I-55/U.S. Rt. 61; EB U.S. Rt. 64-70; NB U.S. Rt. 79. NB U.S. Rt. 61; WB U.S. Rt. 64/70; SB U.S. Rt. 79 near I-55. NB U.S. Rt. 61; WB U.S. Rt. 64/70; SB U.S. Rt. 79 in Memphis. NB U.S. Rt. 61 on the southside of Memphis. NB U.S. Rt. 61 at I-55. A BGS on SB I-55. NB U.S. Rt. 61 near the Mississippi/Tennessee State Line.