If you flop an inside staight draw, with two overcards, it is worth a call, because there are 10 cards that can help you make a playable hand--the four cards to complete your straight, plus three each of your overcards. These odds are roughly the same as if you had an open-ended straight draw or a four-flush.
This tip came from David Sklansky's book, "Hold 'Em Poker"
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