From RxMed, a fairly thourough Orap monograph.

From ADVERSE REACTION NEWSLETTER 1996:4.

FDA Medical Bulletin, Vol 26, No 3, October 1996

Pimozide (Orap) contraindicated with clarithromycin (Biaxin) and other macrolide antibiotics

The labeling for pimozide (Orap), approved for the treatment of Tourette´s disorder, has been updated to contraindicate use of pimozide in patients receiving macrolide antibiotics such as clarithromycin, erythromycin, azithromycin, and dirithromycin. Two sudden deaths have been reported when clarithromycin was added to ongoing pimozide therapy.

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