This information was last updated on 12/16/1999.

Bonnie's original of this information is available at http://www.BonnieGr.com

Make sure that the vitamins are naturally coated, and that no sugar, preservatives, artificial colors or flavors, chemical solvents, or specific things that you may be allergic to are on the label. "USP" on the label is preferred.

The following recommendations are for those 10 yrs to adult (children 6 to 10 should follow the dosages in brackets), who have normal, healthy liver, gallbladder, kidney and heart functions and are not pregnant or nursing, or have active peptic ulcers. Always consult your physician before taking any supplements to be sure. DISCLAIMER: This approach may not work for everyone.

In the morning:

1. Lecithin: 1200 mg granules (1 to 2 tablespoons) or gel cap
2. Antioxidants
   • Beta Carotene: 10,000 I.U. (optional)
   • Vitamin E: 200 I.U. [200 I.U. for children 6-10]
   • Vitamin C: 500 mg
   • Zinc: 30 mg
   • Selenium: 15 mcg (optional)
   • Coenzyme: Q10 30 mg (optional)
   • Glutathione (reduced): 25 mg
3. Vitamin B complex capsule (B50 - 11 B factors) (For under 10 yrs use B25)
   • Vitamin B1 (thiamine): 50 mg
   • Vitamin B2 (riboflavin): 50 mg
   • Vitamin B6 (pyridoxine HCl): 50 mg
   • Vitamin B12 (Cyanocobalamin): 50 mcg
   • Biotin: 100 mcg
   • Pantothenic Acid: 50 mg
   • Folic Acid: 50 mcg to 400 mcg
   • Niacinamide: 50 mg
   • Inositol: 50 mg
   • PABA: 50 mg
   • Choline: 50 mg
4. NO FLUSH niacin (inositol nicotinate): 250 mg (capsule is best) [children 6 to 10 should 125 mg.]
5. Solary Grapenol Grapeseed Extract: 1 mg/pound body weight
6. DHA: 500 mg

1. Niacin: 50 mg of tablets (regular, since no-flush doesn't come in 50 mg doses) [children 6 to 10 should cut this tablet in 1/2 for 25 mg]
   • Niacin may be taken three times during the day as needed for tics - decrease dose if flushing occurs. Flushing feels like a sunburn and may itch or it may be a mild rash. This lasts only 15 minutes and is not an allergic reaction and is not harmful. DO NOT EXCEED 500 MG/DAY (250 MG/DAY FOR CHILDREN 6 TO 10) OF TOTAL NIACIN (NO-FLUSH NIACIN, NIACINAMIDE IN B COMPLEX, AND REGULAR NIACIN). More can be taken with a doctor's supervision - my son is supervised and takes 1600 mg of no-flush niacin a day.

1. Amino Acid Chelated Calcium-Magnesium tablets
   • Calcium: 780 mg
   • Magnesium: 468 mg
   • (6 tablets of Schiff brand provides this)
2. Vitamin B: complex capsule (B50 and for under 10 yrs. B25) as above.
3. Taurine: 500 mg

I give B complex for a balance of the B vitamins, so that a deficiency in one doesn't occur.

Foods that contain tyramine should be avoided if increasing symptoms- they are chocolate (large quantities), aged cheese, soy sauce, red wine, raisins, canned fish, pickled herring, chicken livers, cured meats, and most alcoholic beverages. They interfere with MAO inhibitors, if you are taking this kind of antidepressant, with severe consequences to your health -hypertensive crisis. Tyramine is a monoamine which is eliminated by monoamine oxidase (MAO). If MAO is inhibited, then tyramine is not broken down, releasing stores of norepinephrine, which have been found to be increased in TS in several studies. Tyramine also is an inhibitor of pyridoxal kinase, which decreases the active form of vitamin B6 in the body.

Go to an allergist and get tested for food allergies. Eliminate these foods from your diet to see if this helps, or try an elimination diet without the allergy testing. (Of course, get tested for respiratory allergies also!). Recent studies have shown that food allergies or sensitivites causes hyperactivity in the majority of cases. The allergy connection is also implicated in TS.

Cut out aspartame (NutraSweet). The high phenylalanine blocks other "Large Neutral Amino Acids", such as valine, leucine, isoleucine, tryptophan, tyrosine, histidine, and methionine from entering the brain. Aspartic acid, which is in aspartame, is an excitatory amino acid, which can act as a false transmitter, substituting for glutamic acid (glutamate). MSG (monosodium glutamate) should be avoided, also because of its glutamate portion, which excites neurons. Avoid caramel color, vanillin and yellow #5 (tartrazine). These inhibibit B6 activity.

Avoid pseudephedrine (Sudafed) containing decongestants and antihistamines. Eliminate other dyes (especially azo dyes) that may cause adverse reactions - especially red dye # 40. Caffeine should be eliminated. It is a methylated xanthine stimulant of the catecholamines, which are already stimulated in TS.

Essential fatty acids can be found in DHA and trout, crappie, haddock, sea bass, salmon, cod, and/or cold water halibut (the fatty fish).

Don't ingest many foods high in sugar. The best diet approach may be a semi vegetarian diet, which provides a balance of carbohydrates and protein, recognizing that adolescents need more protein than adults.

For information about my hypothesis and why I have chosen these supplements for my program please see: Bonnie Grimaldi: Hypothesis.

Bonnie Grimaldi, BSMT (ASCP)
Medical Technologist, Laboratory
Mt. Carmel East Medical Center
6001 E. Broad St.
Columbus, Ohio  43213
(614) 234-6700     
 
Bachelor of Science in Medical Technology from the University
   of Akron  in Akron, Ohio  Dec 1977
Graduate courses in Biochemistry at the University of Akron
    towards a Master's degree in Biology
Certified by the American Society for Clinical Pathologists
   MT(ASCP) # 115060 Aug. 1977.

Discalimer: All of the above is the result of Bonnie's research. I take no responsibility for it's accuracy. Please, before beginning any program of this sort, consult with your physician.

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