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The Virus is blamed for killing off all of the adults.  No-one was sure initally where the virus came from, but It was not until the Mallrats had visitted Hope Island, & spoken to Danni, that they discovered that a Pharmaceuticals company called Pandorax had created the virus as the fabled 'Elixir of Life', which would reduce or halt the aging process
Lex, when he caught the virus
Pandorax, an international Pharmaceutical & biotechnological, were working on a Top Secret project, in search of the Elixir of Life.  This experiment went dramatically wrong, & the chemical created decimated the adult population of the world
The effects of 'The Virus' were head & body aches,  their skin would wrinkle, thier hair would go grey, & some would end up so sick they would break out in infected wounds.  In essence, victims were dieing of old age even thought they weren't old
A man with the virus
Lex, Bray & Amber in the Hope Island Labs
Glen with the Virus
The Hope Island Laboratories
"Authorities are appealing for calm throughout the evacuation process. All children under the age of 18 years should report to their local sector for transportation. Priority will be given...to those children exposed to adults already contaminated."
The Newsman spreading the latest on the virus
"CODE 1. Civil Priority. Isolation now in effect. To avoid the risk of contamination please stay indoors and await further instructions. Medical advice will be given."
A newpaper, with a virus news update
With no adults to regulate society, many children formed Tribes of their friends, trying to survive in this descolate world
The only way to recover from the Virus was to take the antidote, the recipe of which was discovered by The Mallrats.
The Antidote