Singulair and steroids
Testosterone (T) has more activity than DHT does, though at the AR that would not be so. singulair and steroids Anabolic steroid effects. Differences also are seen in the male accessory glands of the rabbit and rat. 8 Testosterone propionate and DHT propionate were found to be equally potent in supporting growth and secretory activity of these glands, but the above-mentioned 5a -androstan-3a ,17b -diol was considerably more potent than these in the prostate but completely ineffective in the epidydimis. Furthermore, use of an antiandrogen (AR blocker) did not affect the function of the epidydimis at all. singulair and steroids Anabolic steroid effects. Thus, the activity of testosterone and DHT in this tissue is not via the AR. Are there muscle-building activities that are not via the AR? If the mechanism exists in one tissue it probably does in others as well. Here is an activity that is itself of more interest: regulation of lipolysis (fat release) in adipocytes (fat cells). singulair and steroids Anabolic steroid injections. 9 T, but not DHT, stimulated catecholamine-induced lipolysis. The findings indicated that T but not DHT induced upregulation of b -adrenergic receptors. Use of an aromatase inhibitor did not change these results, so conversion to estrogen was not responsible for the difference. If this activity were via the AR, DHT would also have exhibited this effect. Clearly then, something is going on that is not via the AR. Differential effects of different AAS on human fat cells have also been seen. 10 Oxandrolone was most effective in reducing subcutaneous abdominal fat and visceral fat in obese middle- aged men while weight did not change, as a result of muscle mass increase. Testosterone enanthate gave a small decrease in subcutaneous fat but a slight increase in visceral fat. Nandrolone decanoate also increased visceral fat while decreasing subcutaneous fat. If these activities were via the AR, all three steroids should give the same effects, differing only in potency or the dosage required. There are some interesting studies on sexual receptivity of female rats. Methyltestosterone, methandrostenolone (Dianabol), nandrolone decanoate, and stanozolol all interfered with sexual receptivity (a different result than seen in human bodybuilders) while testosterone propionate did not. 11In male rats,12,13,14 differential activities are also seen. In intact (non-castrated) male rats, testosterone cypionate, nandrolone decanoate, and methandrostenolone (Dianabol) were all able to support male sexual behavior, while methyltestosterone, stanozolol (Winstrol), and oxymetholone eliminated male sexual behavior. Again, these results are different than are seen in human bodybuilders. Testosterone cypionate was able to maintain ejaculation in castrated rats, while oxymetholone (Anadrol) was barely able to do so, and stanozolol was unable to do so. This however might have to do with estrogenic activity - use of an aromatase inhibitor was not tried. Oxandrolone was found incapable of supporting reproductive development in the young male rat. 15 Weight of testes, prostate gland, and seminal vesicles were all below controls, and Leydig cells were severely depleted. Again, it was not ruled out that reduced estrogen levels of the oxandrolone-treated animals might have been to blame, so this does not actually prove a non-AR-dependent mechanism for reproductive development.
Singulair and steroids
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