U.S. Federal Route 21 is a north-south highway in Wythe County. This is the northern most county that this highway passes through. It starts at a junction with Interstate 81 and U.S. Rt. 52. U.S. Rt. 21 passes through the following towns in Wythe County. Wytheville Speedwell U.S. Rt. 21 is not multi-plexed in Wythe County. U.S. Rt. 21 intersects the following highways in Wythe County. Interstate 81, at Wytheville. U.S. Rt. 52, at Wytheville. U.S. Rt. 11, at Wytheville. Virginia Secondary State Route 690, near Crockett. Virginia Secondary State Route 749, at Speedwell.
