U.S. Federal Route 460 runs east-west across a small portion of Mercer Country. This is the only county that U.S. Rt. 460 passes through in West Virginia. U.S. Rt. 460 passes through the following town in Mercer County. Bluefield U.S. Rt. 460 is multi-plexed in Mercer County. U.S. Rt. 52, near Bluefield. U.S. Rt. 19, from near Bluefield to near Princeton. U.S. Rt. 460 intersects the following highways in Mercer County. U.S. Rt. 52, at Bluefield. U.S. Rt. 19, at Bluefield. West Virginia State Route 123, near Bluefield. U.S. Rt. 19, near Princeton. Interstate 77, near Princeton. West Virginia State Route 112, Oakvale.
