U.S. Federal Route 52 runs shortly in Western Cabell County. This highway enters West Virginia from Ohio, and runs due south to Interstate 64 and runs west into Wayne County. U.S. Rt. 52 passes through the following town in Cabell County. Huntington U.S. Rt. 52 is multi-plexed in Cabell County. Interstate 64, at Huntington. U.S. Rt. 52 intersects the following highways in Cabell County. U.S. Rt. 60, at Huntington. Interstate 64, at Huntington.