U.S. Federal Route 52 runs north-south through the entire length of Wayne County. This highway runs along the western edge of not only the county, but the state of West Virginia. U.S. Rt. 52 passes through the following highways in Wayne County. Neal Cyus Hubbardstown Glenhayes Crum U.S. Rt. 52 is multi-plexed in Wayne County. Interstate 64, from the Cabell/Wayne County Line to near Kenova. West Virginia State Route 37, near Fort Gay. U.S. Rt. 52 intersects the following highways in Wayne County. Interstate 64, near Kenova. West Virginia State Route 75, near Neal. West Virginia State Route 37, near Fort Gay. West Virginia State Route 152, near Crum.
