Side affects of anabolic steroids
I guess there is some mystique surrounding chemicals that have the ability to dramatically transform one's physique in a short period of time under the right conditions. side affects of anabolic steroids Anabolic-steroids-chemistry. You would think that people would get bored with this stuff after a while though, right? Well, apparently they don't. Anyway, here is yet another steroid article. But what am I to write about? I had to think about this for a while and finally I decided to talk about the development of some steroids that you never heard of because they never made it to the market. side affects of anabolic steroids Muscles-of-the-body. I guess that by discussing this subject I can make a point about drug development in general that many people do not understand. You see, most people assume that all the great drugs developed by pharmaceutical companies must have ended up being sold to the public. If you develop a potent drug that has a good safety profile than naturally you gotta sell it, right? Well, that is not quite right at all. side affects of anabolic steroids Muscles-of-the-body. In fact, if you talk to pharmaceutical researchers they will tell you that only a very minor percentage of drugs that show great promise in the lab and/or clinical setting ever make it to market. The reasons for this can be many fold - a crowded market place, patent protection issues, prohibitively high cost of production, or lack of categorical sales can be a few. With the cost of getting a drug approved by the FDA for sale in the millions of dollars, as well as the high cost of drug marketing, you can see that some serious picking and choosing has to go on . The result is many very potent and promising drugs - anabolic steroids in this instance - falling through the cracks and never seeing the pharmacy shelves. Research and Development of anabolic steroidsFor you to fully appreciate the things I am going to discuss in this article you have to have a background on how anabolic steroids are screened for activity. As you know, anabolic steroids are derivatives of testosterone which share two types of activity - muscle building (deemed anabolic) and non muscle male sex hormone related activity (deemed androgenic). The goal of researchers in the golden age of anabolic steroid research (1935-1965) was to synthesize a compound which retained a high degree of anabolic activity coupled with a vastly diminished androgenic activity. This property was quantified using what is known as the Anabolic / Androgenic ratio (A/A ratio). The goal was not so much to produce a compound that was strongly anabolic, but rather the goal was to produce a compound with the highest possible A/A ratio. You must understand that the market for anabolic steroids was not bodybuilders / athletes but geriatric patients, patients recovering from surgery or injury, or those suffering from weakness or catabolism secondary to some other disease. These can include men and women, and even children. It was therefore paramount to avoid any virilizing effects when providing such people anabolic treatment, and so an anabolic agent with a very low A/A ratio was needed. To determine the A/A ratio, scientists utilized a test called the Rat Levator Ani Assay. In this test, scientists use two groups of castrated rats. The rats are castrated to remove any interfering influence from fluctuating natural androgen levels.
Side affects of anabolic steroids
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