Rhuematiod arthritis
Drug reactions and Felty's syndrome are rare causes of leukopenia or thrombocytopenia (see below). rhuematiod arthritis New drug for arthritis. The erythrocyte sedimentation rate (ESR) is usually elevated in patients with rheumatoid arthritis and in some patients is a helpful adjunct in following the activity of the disease. (top of section) Serology Rheumatoid factors are antibodies directed against the Fc portion of immunoglobulin G (IgG). A positive test for rheumatoid factor is by no means pathognomonic of rheumatoid arthritis, but is present in 70 to 90% of patients with the disease. rhuematiod arthritis Mouth pain. The titer does not correlate with the activity of disease, but patients with a high titer rheumatoid factor are more likely to have erosive joint disease, extra-articular manifestations, and greater functional disability. In contrast, generally, rheumatoid factor negative patients exhibit a milder disease course. Rheumatoid factors are also detectable in non-rheumatoid patients who have chronic antigenic stimulation, such as prolonged infection (bacterial endocarditis, tuberculosis, cytomegalovirus, human immunodeficiency virus (HIV), collagen vascular disease, or dysproteinemia). rhuematiod arthritis King-of-pain. Low titers of rheumatoid factors may be detected in the serum of apparently normal people, especially over the age of 70, where its prevalence is anywhere from 10 - 25%. The anti-nuclear antibody (ANA) is positive in 20-30% of patients with rheumatoid arthritis and is more common in patients with extra-articular manifestations. (top of section) Radiology Radiological findings early in the disease may show nothing other than soft tissue swelling. Thereafter, periarticular osteopenia may develop. With progression of their disease, narrowing of the joint space is caused by loss of cartilage, and juxta-articular erosions appear, generally at the point of attachment of the synovium. In end-stage disease, large cystic erosions of bone may be seen. Bony proliferation may occur because of degenerative changes that follow inflammation. (slide- erosive changes at the carpal bones). . (top of section) (top of page) Extra-Articular Disease Rheumatoid Nodules Cardiopulmonary Disease Ocular Disease Neurologic Disease Felty's Syndrome Rheumatoid Vasculitis Sjogren's Syndrome Although the joints are almost always the principal focus of the rheumatoid arthritis, other organ systems may also be involved. Extra-articular manifestations of rheumatoid arthritis occur most often in seropositive patients with more severe joint disease.
Rhuematiod arthritis
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