Wisconsin State Route 81 is the main east-west highway across Lafayette County. This connects Darlington to Platteville and Monroe. WI St Rt 81 passes through the following towns in Lafayette County. Darlington
Lamont Argyle WI St Rt 81 is multi-plexed in Lafayette County. Wisconsin State Route 23, near Darlington.
WI St Rt 81 intersects the following highways in Lafayette County. Wisconsin State Route 126, near Lead Mine.