West Virginia State Route 2 is the main north-south highway in Western Ohio County. Two portions of this highway runs along a expressway. WV St Rt 2 passes through the following town in Ohio County. Wheeling WV St Rt 2 is multi-plexed in Ohio County. U.S. Rt. 250, at from the Ohio/Marshall County Line to Wheeling. U.S. Rt. 40, at Wheeling. WV St Rt 2 intersects the following highways in Ohio County. Interstate 470, at Wheeling. U.S. Rt. 250, at Wheeling. West Virginia State Route 251, at Wheeling. Interstate 70, at Wheeling. U.S. Rt. 40, at Wheeling. U.S. Rt. 250, at Wheeling. U.S. Rt. 40, at Wheeling.
