Curriculum Vitae and Scientific References for
Jens Perregaard
| Name: | JENS
KRISTIAN PERREGAARD, PhD |
| Phone: | (+45)47536656 (Denmark) (+34)966718517 (Spain) |
| e-mail: | perregaard.geo@yahoo.com |
| Webpage: | http://www.oocities.org/yosemite/8172 |
| Date of birth: | 23.March 1949 |
| Marial Status: | Married since 1970; A son Michael born 4.12.1971 |
| Latest Position: | Head of
Department of Medicinal Chemistry H. Lundbeck A/S, Ottiliavej 9 DK-2500 Valby, Denmark |
| Education: | Cand Scient
1975 (M.Sc.), specialized in Organic Synthetic Chemistry. Lic. Scient. 1977 (Ph.D.). University of Aarhus Thesis: HMPA as reagent and solvent in organic chemistry I+II |
| Employment: | 1975:
Cheminova A/S 1975-1977: University of Aarhus, Chemical Institute 1975-1977: Teaching at Diakonhøjskolen and Aarhus Teknikum 1977-1979: Organic Geochemistry, The Geological Survey of Greenland 1979-1998: Medicinal Chemistry Research, H. Lundbeck A/S 1998- : Retired |
| Training: | 1977: Organic Geochemistry, University of Newcastle 1977: Organic Geochemistry, Kernforschungsanlage Julich 1977: Organic Geochemistry, IFP/Paris and Elf-Aquitaine/Pau 1979: Wiswesser Line Notation, Paris 1981: NMR Nottingham 1985: NMR, Fallanden 1986: NMR, Upsala 1979-1998: training in Medicinal Chemistry and Management |
| Publications: | 39 scientific publications |
| Patents: | 30 main patent applications and patents |
| Posters: | 20 poster presentations |
| Reviewer: | J.Med.Chem.; Eur.J.Med.Chem.; Current Drugs Ltd. |
| Censor: | Danish Pharmaceutical High School (PhD); Laborantskolen for Hovedstadsområdet (Technicians) |
| Adresses : | Bautahøjvej
44, 3630 Jægerspris, Denmark c/Picos de Europa 11, Ciudad Quesada, 03170 Rojales (Alicante), Spain |
PUBLICATIONS
1. E.B.Pedersen, J.Perregaard, and S.-O.
Lawesson (1973)
Studies on Organophosphorus Compounds -
IV. HMPA as Precursor for Dimethylamine
in Nucleophilic Aromatic Substitution
Reactions.
Tetrahedron, 29, 4211.
2. J.Perregaard, E.B.Pedersen, and S.-O.
Lawesson (1974)
Studies on Organophosphorus Compounds - VII.
Synthesis of Phenolic Esters of N,N-
Dimethylphosphoric Acid Amidates and
N,N-Dimethylphosphoramidochloridic Acid from
HMPA.
Rec. Trav. Chim., Pays-Bas, 93,
252.
3. J.Perregaard, I.Thomsen, and S.-O. Lawesson
(1975)
Studies on Organophosphorus Compounds - XI.
Oxidation of Aromatic Compounds with
Sulphur in Hexamethylphosphoric Triamide
(HMPA). A New Method for Preparation of
N,N-Dimethylthiocarboxamides.
Acta Chem.Scand. , B29, 538.
4. J.Perregaard, I.Thomsen, and S.-O. Lawesson
(1975)
Studies on Organophosphorus Compounds - XII.
About Elemental Sulphur as a Reducing Agent
in Hexamethylphosphoric Triamide (HMPA).
Acta Chem.Scand. , B29, 599.
5. J.Perregaard and S.-O. Lawesson (1975)
Studies on Organophosphorus Compounds - XIII.
About Conversion of Carboxylic Esters into
N,N-Dimethylthiocarboxamides. Synthesis
of 2-Phenylbenzothiazole.
Acta Chem.Scand. , B29, 604.
6. J.Perregaard and S.-O. Lawesson (1977)
Studies on Organophosphorus Compounds - XV.
Synthesis of 2-Arylbenzothiazoles and 2-(a-
Pyridyl)naphthothiazoles by Sulphur Oxidation
in Hexamethylphosphoric Triamide (HMPA).
13C NMR Studies.
Acta Chem.Scand. , B31, 203.
7. J.Perregaard, I.Thomsen, and S.-O. Lawesson
(1977)
Studies on Organophosphorus Compounds - XVI. On
O,O-Dialkyl Dithiophosphoric Acids and
N,N,N´,N´-Tetramethylthiophosphoric Diamide
as Thiation Agents : Conversion of Carboxamide
into Thiocarboxamides, Alkyl
Dithiocarboxylates, or Nitriles.
Bull.Soc.Chim. Belg. , 86, 321.
8. J.Perregaard, B.S. Pedersen, and S.-O.
Lawesson (1977)
Studies on Organophosphorus Compounds - XVII.
About O,O-Diethyl Dithiophosphoric Acid as
Thiation and Alkylation Agent. A New Route to
Dithiocarboxylic Esters and Ethylthioheterocycles.
Acta Chem.Scand. , B31, 460.
9. J.Perregaard, S.Scheibye, H.J.Meyer,
I.Thomsen, and S.-O. Lawesson (1977)
Studies on Organophosphorus Compounds - XVIII.
Oxidation of Tertiary Alicyclic Amines with
Elemental Sulphur in Hexamethylphosphoric
Triamide (HMPA). Oxidative Rearrangements of
Hexahydroazepines and Octahydroazocines to
Bis(3-pyrroll)polysulphides.
Bull.Soc.Chim. Belg. , 86, 679.
10. J. Perregaard (1977)
HMPA som reagens og opløsningsmiddel i
organisk kemi, I+ II.
Ph.D.Thesis, Chemical Institute,
University of Aarhus.
11. J.Perregaard (1978)
Establishment of an Organic Geochemical
Laboratory in GGU.
Rapp.Grønlands Geol.Unders., 90,
150.
12. J.Perregaard and E.J.Schiener (1979)
Thermal Alteration of Sedimentary Organic
Matter by a Basalt Intrusive (Kimmeridgian Shales,
Milne Land, East Greenland).
Chem.Geol., 26, 331.
13. J.Perregaard and E.J.Schiener (1979)
Organic Geochemical and Microscopical Studies
of Sedimentary Organic Matter, Central West
Greenland.
Rapp.Grønlands Geol.Unders., 95,
55.
14. J.Perregaard (1979)
Organic Geochemistry of Sedimentary Organic
Matter from Greenland. A Petroleum Source Rock
Evaluation.
The Geological Survey of Greenland 110 pp.
15. E.J.Schiener and J.Perregaard (1981)
Thermal Maturation of Organic Matter by a Thick
Basaltic Sill in Upper Cretaceous Shales, Svartenhuk
Halvø, Central West Greenland.
Rapp.Grønlands Geol.Unders., 102,
1-16
16. N.Lassen and J.Perregaard (1983)
Synthesis and NMR studies of Z- and E-Isomers
of 10-Oxo and 10-Hydroxy Derivatives of Amitriptyline
and Nortriptyline.
Acta Chem.Scand. , B37,
335-340.
17. J.Arnt, J.Hyttel and J.Perregaard (1987)
Dopamine D-1 Receptor Agonists Combined with
the Selective D-2 Agonist Quinpirole Facilitate the
Expression of Oral Stereotyped Behaviour in
Rats.
Eur.J.Pharmacol., 132(2),
137-145.
18. J.Arnt and J.Perregaard (1987)
Synergistic Interaction Between Dopamine D-1
and D-2 Receptor Agonists: Circling Behaviour of Rats
with Hemitransection.
Eur.J.Pharmacol., 143(1),
45-53.
19. T.Skarsfeldt and J.Perregaard (1990)
Sertindole, a New Neuroleptic with Extreme
Selectivity in A10 Versus A9 Dopamine Neurones in the
Rat.
Eur.J.Pharmacol., 182, 613-614.
20. C.Sanchez, J.Arnt, N.Dragsted, J.Hyttel, H.L.Lembøl,
E.Meier, J.Perregaard, and T. Skarsfeldt (1991)
Neurochemical and in vivo Pharmacological
Profile of Sertindole, a Limbic-Selective Neuroleptic
Compound.
Drug Dev.Res., 22(3), 239-250
21. K.Gundertofte, J.Perregaard, K.P.Bøgesø, J.Hyttel,
and J.Arnt (1991)
QSAR Study on the Neuroleptic and 5-HT2-antagonistic
activities in a series of phenylindoles.
In QSAR : Rational Approaches to the Design
of Bioactive Compounds; C.Silipo and A.Vittoria, Eds;
Elsevier: Amsterdam, 1991; pp 465-468
22. T.Skarsfeldt, J.Arnt, J.Hyttel, E.Meier, J.Perregaard,
C.Sánchez (1991)
Pharmacological Evaluation of Sertindole: A New
Atypical Neuroleptic.
Schizophrenia Research, 4, 326
23. J.Perregaard, J.Arnt, K.P.Bøgesø, J.Hyttel, and
C.Sanchéz (1992)
Noncataleptogenic, Centrally Acting Dopamine
D-2 and serotonin 5-HT2 antagonists within a series of
3-substituted 1-(4-fluorophenyl)-1H-indoles
J.Med.Chem. 35 (6), 1092-1101
24. J.Hyttel, K.P.Bøgesø, J.Perregaard, and C.Sánchez
(1992)
The Pharmacological Effect of Citalopram
Resides in the (S)-(+)-Enantiomer.
J.Neural.Transm.: Gen.Sect. 88(2),
157-160
25. J.Perregaard, K.Andersen, J.Hyttel, and C.Sánchez
(1992)
Selective, Centrally Acting Serotonin 5-HT2
Antagonists. 1: 2- and 6-Substituted 1-Phenyl-3-
(4-piperidinyl)-1H-indoles.
J.Med.Chem. 35, 4813-4822
26. K.Andersen, J.Perregaard, J.Arnt, J.B.Nielsen, and
M.Begtrup (1992)
Selective, Centrally Acting Serotonin 5-HT2
Antagonists. 2: Substituted 3-(4-fluorophenyl)-
1H-indoles.
J.Med.Chem. 35, 4823-4831
27. J.Perregaard, J.Arnt, and C.Sánchez (1993)
Recent Developments in Anxiolytics.
Current Drugs ,Current Opinion in
Therapeutic Patents, January 1993, 101-128p
28. K.Andersen, T.Liljefors, K.Gundertofte, J.Perregaard,
and K.P.Bøgesø (1994)
Development of a Receptor-Interaction Model for
Serotonin 5-HT2 Receptor Antagonists.
Predicting Selectivity with Respect to Dopamine
D2 Receptors.
J.Med.Chem. 37, 950-962
29. K.P. Bøgesø, K. Andersen, J. Arnt, K. Frederiksen, J.
Hyttel, J. Perregaard, and
T. Skarsfeldt (1995)
Design of Atypical Antipsychotic Drugs ?
Proceedings of the Alfred Benzon Symposium, 38,
Schizophrenia, An Integrated View,
p 361-374, Eds. R.Fog, J. Gerlach, R.
Hemmingsen, Munksgaard, Copenhagen 1995.
30. J. Perregaard, E. K. Moltzen, E. Meier, and C. Sánchez
(1995)
Sigma Ligands with Subnanomolar Affinity and
Preference for the s2 Binding Site. Part 1.
3-(w-Aminoalkyl)-1H-indoles.
J.Med.Chem. 38, 1998-2008.
31. E. K. Moltzen, J. Perregaard, E. Meier (1995)
Sigma Ligands with Subnanomolar Affinity and
Preference for the s2 Binding Site. Part 2.
Spiro-joined Benzofuran, Isobenzofuran, and
Benzopyran Piperidines.
J.Med.Chem. 38, 2009-2017.
32. J. Perregaard, F. Højelse, and F.W. Andersen (1995)
Eco-toxicological, Toxicological, and
Physical-Chemical Investigations of Potassium 2,5-
Dichlorobenzoate and Potassium
N-(4-Fluorophenyl)glyucinate.
Dansk Kemi 3, 14-15.
Chem.Abstr. 1997, 126, 26646
33. K. Sakamoto, Y. Nakamura, S. Aikoh, T.Baba, J.
Perregaard, H. Pedersen, E.K. Moltzen,
D. J. Mulford, and T. Yamaguchi (1995)
Metabolism of Sertindole : Identification of
the Metabolites in the Rat and Dog, and other
Species Comparison of Liver Microsomal
Metabolism.
Xenobiotica 25 (12), 1327-1343.
34. K.Andersen, T.Liljefors, J.Hyttel, and J.Perregaard
(1996)
Serotonin 5-HT2 Receptor, Dopamine D2
Receptor and a1 Adrenoceptor Antagonists.
Conformationally Flexible Analogues of the
Atypical Antipsychotic Sertindole.
J.Med.Chem. 39, 3723-3738.
35. C.Sánchez, J.Arnt, B.Costall, M.E.Kelly, E.Meier,
R.J.Naylor, and J. Perregaard (1997)
The Selective s2-ligand
Lu 28-179 has potent anxiolytic-like effects in rodents.
J.Pharmacol. & Exp. Ther. 283
(3), 1323-1332
36. E.Falch, J.Perregaard, B.Frølund, B.Søkilde,
A.Buur, L.M.Hansen, K.Frydenvang, L.Brehm,
T.Bolvig, O.M.Larsson, C.Sanchez, A.Schousboe,
and P.Krogsgaard-Larsen (1999)
Selective Inhibitors of Glial GABA Uptake:
Synthesis, Absolute Stereochemistry and Phar-
macology of the Enantiomers of
3-Hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole
( Exo-THPO) and analogues.
J.Med:Chem (published)
37. T.Balle, J.Perregaard, S.Larsen, T.Ramirez, K.K.Søby, T.Liljefors,
and K. Andersen (2002)
Synthesis and Structure-Affinity Relationship
Investigations of 5-Aminomethyl and 5-Carbamoyl
Analogues of the Antipsychotic Sertindole. A
New Class of Selective
PATENTS
1. Jens Kristian Perregaard;
3-Substituted
4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridines and their pharmaceutical compositions.
GB 80-38139, 1980; Chem.Abstr. 1982,97,
182394q
2. Jens Kristian Perregaard;
2-acyl-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ones, their use as medicines and their
pharmaceutical compositions.
GB 80-38140,1980;Chem.Abstr. 1982,
97, 182395r
3. Jens Kristian Perregaard;
Phenylindene derivatives, acid addition salts
thereof, and methods of preparation.
Jpn.Kokai Tokkyo Koho JP 5989661, 1984; Chem.Abstr.
1985,102, 24484m
4. Jens Kristian Perregaard;
Indole derivatives and their antipsychotic
activity.
US Patent No. 4,710,500, 1987; Chem.Abstr.
1986, 106, 67110m
5. Jens Kristian Perregaard;
Process for the preparation of haloperidol
acetate and pharmaceutical composition
thereof.
European Patent Application No. 87-307799,
1987; Chem.Abstr. 1988,109, 37741n
6. Klaus Peter Bøgesø, Jens Kristian Perregaard;
Preparation and formulation of 3-aminomethyl
derivatives of indan, indoline, dihydro-
benzofuran and dihydrobenzothiophene for
treatment of central nervous system disorders.
European Patent Application No. 88-301073,
1988; Chem.Abstr. 1988,110, 75302y
7. Klaus Peter Bøgesø, Jens Kristian Perregaard;
Pharmaceutically useful
(+)-1-(3-dimethylaminopropyl)-1-(4´-fluorophenyl)-1,3-dihydro-
isobenzofuran-5-carbonitrile and non-toxic acid
addition salts thereof.
US Patent No. 4,943,590, 1991; Chem.Abstr.
1989, 113, 78150v
8. Jens Kristian Perregaard, John W. Stenberg;
Preparation of piperazinyl derivatives, and
their use as serotonergic agonists in the treatment
of central nervous system disorders
US Patent No. 5,002,948, 1991; Chem.Abstr.
1990, 114, 17582m
9. Jens Kristian Perregaard, Torben Skarsfeldt;
Pharmaceutical compositions containing and use
of Sertindole for the treatment of schizophrenia
European Patent Application No. 90-610022,
1990; Chem.Abstr. 1990,114, 221411j
10. Jens Kristian Perregaard, Henrik Pedersen, Kim Andersen, Klaus Peter
Bøgesø;
Preparation of 1-aryl-3-piperidylindoles as CNS
agents
European Patent Application No. 91-610055,
1991;Chem.Abstr. 1992, 116, 151564b
11. Jens Kristian Perregaard, Brenda Costall;
Preparation of 3-(4-piperidinyl)-N-arylindoles
as anxiolytics
Application No. WO 9200070, 1992;Chem.Abstr.
1992, 116, 194150f
12. Jens Kristian Perregaard, Kim Andersen;
Preparation of 3-arylindole and 3-arylindazole
derivatives as 5-HT2 antagonists
European Patent Application No. 91-610058,
1991;Chem.Abstr. 1992, 116, 235431u
13. Jens Kristian Perregaard, Henrik Pedersen;
Preparation of sertindole prodrugs
Application No. WO 9206089, 1992;Chem.Abstr.
1992, 117, 234011r
14. Jens Kristian Perregaard, Brenda Costall;
1-Aryl-3-(4-piperidyl)indole derivatives for
treatment of addiction to drugs and substances
of abuse
Application No. WO 9215302, 1992;Chem.Abstr.
1992, 117, 247029c
15. Jens Kristian Perregaard, Brenda Costall;
Arylpiperidylindole derivatives for treatment
of cognitive disorders
Application No. WO 9215303, 1992; Chem.Abstr..
1992, 118, 825c
16. Jens Kristian Perregaard, Nils Dragsted;
Treatment of hypertension and peripheral
vascular diseases with 1-aryl-3-(4-piperidyl)indoles.
Application No. WO 9215301, 1992; Chem.Abstr.
1992, 118, 27472x
17. Ejner K. Moltzen, Jens Kristian Perregaard;
4-(Phenylalkyl)piperidines, e.g.
spiro-1(3H),4´-piperidine] derivatives, and their use for the
treatment of mental disorders.
European Patent Application No. 92-610044,
1992; Chem.Abstr. 1993,119, 117118m
18. Jens Kristian Perregaard, Torben Skarsfeldt;
Use of arylindole derivatives for the treatment
of psychoses.
Application No. WO 9312790, 1993; Chem.Abstr.
1993, 119, 152106
19. Jens Kristian Perregaard, John W. Stenberg, Ejner K. Moltzen
Preparation and formulation of dimeric
piperidine, tetrahydropyridine, and piperazine derivatives
as nervous system agents.
Application no. WO 9325527, 1993; Chem.Abstr.
1994, 120 , 270124a
20. Jens Kristian Perregaard
Preparation and formulation of
aminomethylindans, -benzofurans and benzothiophenes as 5-HT1A
receptor agonists
Application no. WO 9413620 , 1994; Chem.Abstr.
1994, 121, 205201
21. Ejner K. Moltzen, Jens Kristian Perregaard, Henrik
Pedersen
New fused benzo derivatives are 5-HT1a
receptor ligands - useful for treating anxiety, depression,
psychosis, impulse control disorders, alcohol
abuse etc.
Application no. WO 9413659, 1994; Chem.
Abstr. 1994, 122, 290887
22. Jens Kristian Perregaard, Ejner K. Moltzen, Kim
Andersen, Henrik Pedersen., Klaus P. Bøgesø,
Andre Pernet, Barbara Bopp, Darcy Mulford,
Kiyoshi Sakamoto.
Preparation of
chloro(fluorophenyl)[[(dihydroimidazolonyl)ethyl]piperidinyl]indole 5-HT2 receptor
antagonists.
Application no. WO 9512591, 1995; Chem.
Abstr. 1995, 123, 228185
23. Kim Andersen, Jens Kristian Perregaard
Preparation of 1-arylindole-3-alkanamines and
analogs as serotoninergic S2-antagonists.
Application no. WO 9516684, 1995; Chem.
Abstr. 1995, 123, 313758
24. Jens Kristian Perregaard, John W. Stenberg, Bitten
Hansen
Preparation of N-(indanylmethyl)piperidines and
-piperazines and analogs as 5- HT1A and/or
5-HT2A ligands.
Application no. WO 9533721, 1995; Chem.
Abstr. 1996, 124, 232261
25. Jens Kristian Perregaard and Ejner K. Moltzen.
Serotonin 5-HT1A and dopamine D2
receptor ligands.
Application no. WO 9533729, 1995; Chem.
Abstr. 1996, 124, 261070.
26. E. Falch, J.K. Perregaard, Sibylle Moltzen Lens, A.
Schousboe, P. Krogsgaard-Larsen,
B. Frølund, S.L. Moltzen.
Preparation of 4-aminotetrahydrobenzisoxazole
and -isothiazole GABA-uptake inhibitors
Application no. WO 9626929, 1996; Chem.Abstr.
1996, 125, 275857
27. Jens Kristian Perregaard, Benny Bang-Andersen, Henrik
Pedersen, Ivan Mikkelsen and Robert
Dancer.
Preparation of Indane and Dihydroindole
Derivatives as Dopamine D4 Receptor, 5-HT Receptor,
and 5-HT transporter Ligands.
Application no. WO 9828293, 1997;
Chem.Abstr. 1998, --, 479524
28. Jens Kristian Perregaard, Ivan Mikkelsen, and , Henrik Pedersen.
Preparation of Indane or Dihydroindole
Derivatives as Psychotropics.
Application no. WO 9828290, 1997; Chem.Abstr.
1998, --, 479521
29. Ejner K. Moltzen and Jens Kristian Perregaard
Indole and 2,3-dihydroindole derivatives, their
preparation and use (1997)
(application submitted)
30. Jens Kristian Perregaard and Kim Andersen
5-Heteroaryl substituted indoles as alfa1
antagonists (1998)
(application submitted)
POSTERS
1. H.Nielsen, J.Perregaard (1983)
Identification of Tefludazine Metabolites in
biological material by 1H-NMR
2. J.Perregaard, K.P.Bøgesø, J.Arnt,
A.V.Christensen, J,Hyttel, J.J.Larsen (1985)
Potent neuroleptic activity in a series of
phenylindenes, -indoles, and -indazoles
Presented at 3rd SCI-RSC Medicinal Chemistry
Symposium, 15-18 Sept. 1985, Cambridge, England
3. J.Perregaard, T.Skarsfeldt, J.Arnt,
J.Hyttel, C.Sanchez, K.P.Bøgesø (1990)
Sertindole, a new atypical neuroleptic.
Presented at XIth International Symposium on
Medicinal Chemistry, 1990, Jerusalem, Israel
4. T.Skarsfeldt, J.Arnt, J.Hyttel, E.Meier,
J.Perregaard, C.Sánchez (1990)
Pharmacological profile of sertindole: A new
atypical Neuroleptic.
Presented at XVII CINP, 1990, Kyoto, Japan
5. J.Arnt, T.skarsfeldt, J.Hyttel,
J.Perregaard, C.Sánchez (1990)
Sertindole, a new atypical neuroleptic.
Soc.Neurosci.Abstract , 1990, 16,248,
Abstr.109.9
6. T.Skarsfeldt, J.Arnt, J.Hyttel, E.Meier,
J.Perregaard, C.Sánchez (1991)
Pharmacological Evaluation of Sertindole : A
new Atypical Neuroleptic.
Presented at International Congress on
Schizophrenia Research, Tucson, Arizona, April 21-25 1991
7. J.Perregaard, J.Arnt, J.Hyttel (1991)
3-Indolylbutyl- and
3-(2,3-dihydroindolyl)butylpiperazines as partial 5-HT1A agonists.
Presented at 8th Camerino-Noordwijkerhout
Symposium, 8-12 sept.1991, Camerino, Italy
8. K.Andersen, J.Perregaard, J.Arnt, J.Hyttel,
C.Sánchez (1992)
Selective, centrally acting serotonin 5-HT2
antagonists within series of substituted phenylindoles.
Presented at 204th ACS National Meeting,
Washington DC, August 23-28 1992
9. J.Perregaard, K.Andersen, J.Arnt, J.Hyttel,
C.Sánchez (1992)
Selective, centrally acting serotonin 5-HT2
antagonists within series of substituted phenylindoles.
Presented at XIIth International Symp. on
Medicinal Chemistry, Basel sept.13-17 1992.
10. E.K.Moltzen, J.Perregaard, E.Meier, C.Sánchez, J.Arnt,
J.B.Nielsen (1992)
Spiro-cyclic isobenzofuran derivatives: a new
class of high-affinity sigma ligands with potent anxiolytic
activities.
Presented at XIIth International Symp. on
Medicinal Chemistry, Basel sept.13-17 1992.
11. K.Andersen, T.Liljefors, K.Gundertofte, J.Perregaard,
K.P.Bøgesø (1993)
Development of a Receptor-Interaction Model for
Serotonin 5-HT2 Receptor Antagonists.
Presented at 9th Noordwijkerhout-Camerino
Symposium, Noordwijkerhout 23- 27 May 1993.
12. J.Perregaard, E.K.Moltzen, E.Meier, C.Sánchez and
J.Hyttel (1993)
4-Phenylpiperidines and 4-spiropiperidines with
sub-nanomolar affinity for sigma binding sites and
with potent anxiolytic activity.
Presented at 23 rd Soc.Neurosci., Washington
DC, November 7-12 1993. Abstr. 19, 763.16.
13. J.Perregaard, T. Skarsfeldt, K.Andersen, K.P.Bøgesø,
K.Frederiksen (1994)
Structural Analogues of the Antipsychotic
Sertindole. Studies on the Firing of Dopamine Neurons
in A10 and A9 Rat Brain Areas after Chronic
Administration.
Presented at 24th Soc.Neurosci., Miami,
November 13-18 1994. Abstr. 20, 726.11
14. E.K.Moltzen, J.Perregaard, E.Meier (1994)
Spiro-cyclic Piperidine Derivatives :
Structure-Affinity Studies of High-Affinity Sigma Ligands Related
to Lu 28-179.
Presented at XIIIth International Symp. on
Medicinal Chemistry, Paris September 19-23 1994.
15. C.Sánchez, J.Arnt , J.Perregaard (1994)
Lu 28-179 - A Selective Sigma Ligand with
Potent Anxiolytic Effects.
Presented at 24th Soc.Neurosci., Miami,
November 13-18 1994. Abstr. 20, 164.16
16. K.Andersen, J.Perregaard, T.Liljefors, J.Hyttel (1995)
Serotonin 5-HT2A, Dopamine D2
and Noradreline a1 Antagonists - Analogues of the Atypical
Antipsychotic Sertindole.
Presented at the 210th ACS Meeting, Chicago,
August 1995. Abstracts of Papers American
Chemical Society 210 (1-2), MEDI 130.
17. J.Perregaard, J.Arnt, C.Sanchez (1996)
High-Affinity Serotonin 5-HT1A
Ligands Within a Series of 6-Substituted 1- Indanmethylamines.
Presented at 26th Soc.Neurosci., Washington,
November 16-21 1996, Abstr.
18. E.K. Moltzen, J.Perregaard, J.Arnt (1996)
Structure-Activity Relationships of a Series of
5-HT1A Agonists / D2 Antagonists : Potential
Antipsychotics.
Presented at 26th Soc.Neurosci., Washington,
November 16-21 1996, Abstr.
19. Petersen K; Olesen O F; Perregaard J K ; Mikkelsen J D
(1997)
Synuclein-NACP mRNA expression in rat
hippocampus and cerebral cortex during development
Presented at 27th Annual Meeting of the Society
for Neuroscience, Part 1, New Orleans, Louisiana,
USA, October 25-30, 1997. Abstr. 23 (1-2).
1997. 267.
20. Bang-Andersen B; Pedersen, H; Perregaard, J (1998)
Dopamine D4 Ligands with action on
5-HT Receptors and/or 5-HT-Uptake Sites within a series of
Indanes and Indolines.
Presented at the 216th American Chemical
Society National Meeting, Boston, USA, 23-27 August 1998.
Updated 02-05-2002 Jens Perregaard