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Akamai
Akamai (Akamai Technologies) is a huge data warehousing service. Basically, their deal is that they provide space for other companies and host their content. Among that content is ads. Akamai also provides 'useful' content hosting; many websites keep their graphics on Akamai. Norton's uses Akamai to host their Anti-Virus updates so millions of people don't try to all try to log on to Norton's own site, resulting in faster and more convenient downloading.
The downside is not just the ads, though, but the data collection and other junk that comes with it. There are a number of spyware makers that use ads served from Akamai, and also possibly do data collection there. Like any ad site, Akamai sites can also serve cookies which may contain personal or sensitive information.
Akamai sites often use aliases. For example a188.x.akamai.net is also called media.washingtonpost.com. Visit the Washington Post site, and you might see your browser fetching info from media.washingtonpost.com. But it's actually run by Akamai. So what is the point? The point is some types of blocking, like DNSKong and especially HOSTS, is mostly useless to stop stuff like this, which is why this site advocates using a combined approach with Kerio, DNSKong, and other methods.
(If this is way over your head, don't worry about it - just take by advice and use both the Kerio blocklist and DNSKong.)
There are two Akamai blocks that are disabled, as you'll see on the next explanation page. The 205.188.221.x is a mixed story. Some of the IPs are used as ad sites for spyware (205.188.221.x), but some IPs are also used for legitimate services and popular sites. So, filtering this block completely might block one or two ad sites but it will also block valuable content to popular websites. Since these two are not known to do any actual data collection -- just serve ads -- it wasn't worth it to block. If you use DNSKong with the blockfile from this site, you'll be covered anyway.
The other block, 64.12.145.x is used by many popular sites, so it was decided that this one was best left unblocked. (Again, if this is way over your head, just leave these rules alone. The MAIN thing is that as long as your Anti-Virus software and other legitimate programs that use updates from Akamai-owned sites can get them, you don't have to play around with anything.)

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