Updates and patches

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Microsoft Windows

Microsoft Windows Update: Windows Update is a catalog of fixes, updates, and enhancements to Windows and many programs that work with Windows.
Microsoft Office Product Updates: Find the latest Office product updates for this computer.
Microsoft Baseline Security Advisor: MBSA runs on Windows 2000 and Windows XP systems and will scan for missing hotfixes and vulnerabilities in the following products: Windows NT 4.0, Windows 2000, Windows XP, Internet Information Server (IIS) 4.0 and 5.0, SQL Server 7.0 and 2000, Internet Explorer (IE) 5.01 and later, and Office 2000 and 2002.
Microsoft Security: The Microsoft Security site has a wide range of security content, prominent links to security information across Microsoft.com, and pointers to the latest automated updating tools.
CNET.com's Catchup: With CNET.com's Catchup service, automatically find software updates, patch security vulnerabilities, and detect adware to keep your PC healthy and up-to-date.
VersionTracker.com: VersionTracker.com is a free Windows software download site for Microsoft Windows updates, upgrades, and patches.

Apple Macintosh

Apple - Mac OS X - How to Upgrade - Software Updates: If Apple Software Update finds an item to download, it appears in a list. You can click on an item to get a description before downloading it.
Mactopia: Microsoft Product Updates: Downloadable updates, converters, utilities and templates for Microsoft products that run on Macintosh OS, in .bin and .hqx formats.
VersionTracker.com For Mac OS
VersionTracker.com For Mac OS X: VersionTracker.com is a free Macintosh software download site for the Macintosh.

Tips and How-Tos

About.Com: Tips for Safer Computing
AVERT Research Center - Anti-Virus Tips
Brainbuzz.com: Practicing Safe Computing
CERT® Coordination Center: Home Network Security: This document gives home users an overview of the security risks and countermeasures associated with Internet connectivity, especially in the context of "always on," or broadband access services (such as cable modems and DSL). However, much of the content is also relevant to traditional dial-up users (users who connect to the Internet using a modem).
F-Secure: Instructions to make your computer immune to VBS script attacks.: This pages gives instructions on how to either remove Windows Scripting Host from your machine or to disassociate *.vbs files from Windows Scripting Host.
How to Stay Virus, Worm and Trojan Free - Without Anti-Virus Software: There's no doubt that anti-virus software is here to stay but there are many things that can be done to prevent or reduce the risk of virus infection and the subsequent effects of such an infection. There are a host of working procedures and policies and some software alternatives that have the potential to greatly reduce your risk levels.
Trend Micro's Safe Computing Guide: To reduce the risk of virus infections, and of inadvertently triggering or spreading them to other people, Trend Micro would like to share some easily implemented "safe computing" practices. Put these into effect on your machine today and they will help keep you using today’s advanced computer information access technology without falling prey to viruses and other malicious code!

Tools & Utilities

F-Prot for DOS Download / Update Utility
F-Secure Corporation--Virus removal and Other Tools
McAfee - AVERT--Virus Tools
PandaSoftware--Free Virus Repair Tools
Symantec Security Response - Removal Tools Page
Jason Levine's Toolbox: Script Sentry: Script Sentry allows safe scripts to run on your system while alerting you if a script might harm your system. In addition, Script Sentry prevents against malicious scripts hidden in ShellScrap (hidden SHS and SHB extensions) files, Word/Excel macro viruses, malicious HTA files, and accidentally run REG files.

Virus Calendars

AVERT Research Center - Virus Calendar: The viruses shown below can infect a system 365 days a year. But on the payload dates designated on this calendar, the viruses may do more than just infect you. While these payloads may just be a nuisance, some may severely damage your system. Virus payloads vary, but it is important to know what a payload is capable of so you can determine the risk. AVERT is constantly on the lookout for new virus threats and will keep this calendar updated with the latest viruses that have a dangerous payload.
Symantec: Virus Calendar