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Main Engineering is usually located in a starship's engineering section, from where the ship's main power systems are controlled.

Its primary purpose is to be the central point for control of all engineering systems aboard a starship, especially those related to propulsion and power generation. The Matter/Antimatter Reaction Chamber (also known as the warp core) is located in Main Engineering.

In case of emergencies, Main Engineering can be turned into a command and control center by converting a number of consoles to duplicate the stations on the Main Bridge. The software is already preloaded onto these consoles and each vessel has specific procedures in place in case a situation warrants.
Defiant Matter/Antimatter Warp Core