Khadija al-Kubra daughter of Khuwaylid ibn (son of) Asad ibn Abdul-`Uzza ibn Qusayy belonged to the clan of Banu Hashim of the tribe of Banu Asad.
She was a distant cousin of her husband the Messenger of Allah Muhammad ibn Abdullah ibn Abdul-Muttalib ibn Hashim ibn Abd Manaf ibn Qusayy, Allah's peace and blessings be upon him and his progeny.
Qusayy, then, is the ancestor of all clans belonging to Quraysh. According to some historians, Quraysh's real name was Fahr, and he was son of Malik son of Madar son of Kananah son of Khuzaimah son of Mudrikah son of Ilyas son of Mazar son of Nazar son of Ma`ad son of Adnan son of Isma'il (Ishmael) son of Ibrahim (Abraham) son of Sam son of Noah, peace and blessings of Allah be upon the prophets from among his ancestors.
According to a number of sources, Khadija was born in 565 R and died one year before the Hijra (migration of the Holy Prophet and his followers from Mecca to Medina) in 623 R. at the age of 58, but some historians say that she lived to be 65. Khadija's mother, who died around 575 R., was Fatima daughter of Za'ida ibn al-Asam of Banu 'Amir ibn Luayy ibn Ghalib, also a distant relative of Prophet Muhammad (peace be upon him).
Khadija's father, who died around 585 R., belonged to the Abd al-`Uzza clan of the tribe of Quraysh and, like many other Qurayshis, was a merchant, a successful businessman whose vast wealth and business talents were inherited by Khadija and whom the latter succeeded in faring with the family's vast wealth. It is said that when Quraysh's trade caravans gathered to embark upon their lengthy and arduous journey either to Syria during the summer or to Yemen during the winter, Khadija's caravan equalled the caravans of all other traders of Quraysh put together.